Histone cluster 2 H3A Inhibitors
Histone cluster 2 H3A inhibitors pertain to a specialized chemical class designed to selectively target and modulate the activity of histones within the cluster 2 H3A subgroup. Histones are integral proteins involved in organizing and packaging DNA into structural units called nucleosomes. In this context, Histone cluster 2 H3A specifically refers to a subgroup within the histone family, encompassing variants of H3A, a type of histone H3. Histone H3 variants, including H3A, contribute significantly to chromatin structure and play a crucial role in epigenetic regulation by influencing gene expression.
The inhibitors developed for Histone cluster 2 H3A are intricately designed to interact with the specific structural features of these histones, aiming to disrupt their normal interactions within the chromatin environment. By selectively inhibiting the functions of H3A within this histone cluster, researchers seek to unravel the nuanced roles of this histone variant in various cellular contexts. Understanding the regulation and dynamics of histones, particularly within specific clusters like Histone cluster 2 H3A, contributes to a broader comprehension of epigenetic mechanisms, shedding light on how chromatin structure influences gene activity and cellular processes. The study of Histone cluster 2 H3A inhibitors represents an essential avenue for advancing our understanding of chromatin biology and the intricate molecular mechanisms governing gene regulation at the epigenetic level.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure and gene expression, potentially reducing histone gene transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid functions as a histone deacetylase inhibitor, which can disrupt histone modification and subsequently histone gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a DNA methyltransferase inhibitor and can lead to hypomethylation of DNA, affecting the transcription of various genes including histones. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor, which may lead to changes in chromatin structure and downregulation of histone gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, or SAHA, is a potent histone deacetylase inhibitor that can change gene expression patterns, possibly reducing histone gene transcription. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat inhibits class I/IV histone deacetylases and might decrease the expression of certain genes, including histones, by altering chromatin accessibility. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin, a cyclic peptide, inhibits histone deacetylase, potentially affecting the expression of histone genes by modifying chromatin structure. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a broad-spectrum histone deacetylase inhibitor that may impact histone expression by altering chromatin compaction and gene transcription. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat selectively inhibits class I histone deacetylases and could result in epigenetic modulation of histone gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor that can lead to DNA hypomethylation and may alter histone gene expression patterns. | ||||||