HIGD2A Inhibitors
Chemical inhibitors of HIGD2A can directly or indirectly influence the functional activity of this protein through various mechanisms. Coenzyme Q10, a key component of the mitochondrial electron transport chain, can disrupt the mitochondrial membrane potential, leading to a dysfunction of HIGD2A which plays a role in maintaining mitochondrial integrity. Similarly, Antimycin A and Atovaquone, by targeting complex III, and Rotenone, Fenpyroximate, and Pyridaben, by inhibiting complex I of the electron transport chain, induce mitochondrial dysfunction. This impairment of mitochondrial function is likely to hinder the activity of HIGD2A, which is closely associated with mitochondrial health. Oligomycin A, by inhibiting ATP synthase, can affect mitochondrial energy production, thus potentially impairing HIGD2A's ability to maintain mitochondrial function. CCCP acts as a mitochondrial uncoupling agent, dissipating the mitochondrial membrane potential, a crucial factor for normal mitochondrial function and indirectly for HIGD2A's function.
Furthermore, Zinc pyrithione and Auranofin can induce oxidative stress in mitochondria, which can lead to the disruption of mitochondrial integrity, thereby inhibiting HIGD2A's function indirectly. The disruption of mitochondrial integrity and function through oxidative stress and membrane potential collapse is a common theme among these inhibitors. Thenoyltrifluoroacetone, by chelating essential metal ions, can interfere with mitochondrial enzymes, disrupting the environment where HIGD2A operates. Stigmatellin, by specifically targeting the cytochrome b subunit within complex III, can compromise the electron transport chain, leading to an indirect inhibition of HIGD2A. These chemicals, by impairing mitochondrial function or the membrane potential, can have a significant impact on the functionality of HIGD2A, which is critical for the maintenance of mitochondrial integrity and the efficient operation of the electron transport chain.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10, involved in the mitochondrial electron transport chain, can inhibit HIGD2A by potentially disrupting the mitochondrial membrane potential and electron transport efficiency, where HIGD2A functions. This could lead to a functional inhibition of HIGD2A's role in maintaining mitochondrial integrity and efficiency. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A, a known inhibitor of the mitochondrial electron transport chain complex III, can indirectly inhibit HIGD2A by causing a dysfunction in mitochondrial respiration, potentially disrupting the membrane potential where HIGD2A is known to have an important role. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A inhibits ATP synthase in mitochondria. Given that HIGD2A is involved in mitochondrial respiration, inhibition of ATP synthase can lead to mitochondrial dysfunction, which in turn can functionally impair HIGD2A's role in the maintenance of mitochondrial integrity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. The inhibition of complex I can create oxidative stress and impair mitochondrial function, which would likely disrupt the functional activity of HIGD2A, especially considering its role in maintaining mitochondrial health. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc pyrithione can disrupt mitochondrial membrane potential and induce oxidative stress, which indirectly can inhibit HIGD2A by damaging the integrity of mitochondria where HIGD2A functions. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
CCCP is a mitochondrial uncoupling agent that can inhibit HIGD2A by dissipating the mitochondrial membrane potential, an essential component of mitochondrial function where HIGD2A is known to operate. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
This compound is a chelator of metal ions that are cofactors for various enzymes. It can indirectly inhibit HIGD2A by disrupting mitochondrial enzyme activities that are essential for maintaining the proper function of mitochondria, thereby potentially impairing the role of HIGD2A in these processes. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin targets thioredoxin reductase, which can cause an increase in oxidative stress within cells. This increase in oxidative stress can lead to mitochondrial dysfunction, thereby indirectly inhibiting HIGD2A's function in maintaining mitochondrial integrity. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $270.00 | 2 | |
Atovaquone selectively inhibits the cytochrome bc1 complex (complex III) in mitochondria. By inhibiting this complex, it can cause a dysfunction in the electron transport chain, which can indirectly inhibit HIGD2A, given the protein's involvement in mitochondrial processes. | ||||||