HIGD2A Activators
HIGD2A Activators are a unique class of compounds that can influence the activity of HIGD2A, a protein involved in cellular energy metabolism. The compounds Nitric oxide, Sildenafil, 8-Bromo-cGMP, Forskolin, 8-Bromo-cAMP, Isoproterenol, Epinephrine, Dopamine, ATP, Calcium chloride, Calmidazolium chloride, and Okadaic acid all interact with pathways or processes that can enhance the functional activity of HIGD2A. Cyclic nucleotides and their associated kinases can enhance the activity of HIGD2A. Nitric oxide, Sildenafil, and 8-Bromo-cGMP can increase the activity of protein kinase G (PKG) in the cGMP pathway, which can phosphorylate HIGD2A or its interacting proteins, thereby enhancing its activity. Similar mechanisms are employed by Forskolin, 8-Bromo-cAMP, Isoproterenol, Epinephrine, and Dopamine, which can increase the activity of protein kinase A (PKA) in the cAMP pathway to enhance HIGD2A activity.
ATP, as a direct activator of many protein kinases, can enhance HIGD2A activity by increasing the activity of kinases. Calcium ions, via Calcium chloride, can activate calmodulin, which in turn can activate calmodulin-dependent protein kinases to enhance HIGD2A activity. Calmidazolium chloride, a calmodulin antagonist, can indirectly influence the activation of calmodulin-dependent protein kinases, potentially affecting HIGD2A activity. Lastly, Okadaic acid, by inhibiting protein phosphatases 1 and 2A, can maintain the phosphorylated (active) state of kinases that enhance HIGD2A activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $104.00 $354.00 | 7 | |
8-Bromo-cGMP is a membrane-permeable cGMP analog. It can directly stimulate PKG, which can then enhance HIGD2A activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin stimulates adenylyl cyclase, which increases intracellular levels of cyclic AMP (cAMP). cAMP can activate protein kinase A (PKA), which can enhance HIGD2A activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It can directly activate PKA, which can then enhance HIGD2A activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist. It can stimulate adenylyl cyclase via the beta-adrenergic receptor, leading to increased cAMP and PKA activity, potentially enhancing HIGD2A activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adenylyl cyclase via adrenergic receptors, increasing cAMP levels and subsequently PKA activation, potentially leading to enhanced HIGD2A activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can activate adenylyl cyclase via D1-like dopamine receptors, leading to increased cAMP and PKA activation, potentially enhancing HIGD2A activity. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions can activate calmodulin, which in turn can activate calmodulin-dependent protein kinases. These kinases can enhance HIGD2A activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can enhance the phosphorylated (active) state of kinases that enhance HIGD2A activity. | ||||||