HDDC3 Activators
HDDC3 Activators encompass a variety of chemical compounds that indirectly enhance the functional activity of HDDC3 through modulation of different signaling pathways. For instance, Forskolin and Isoproterenol both increase intracellular cAMP, indirectly promoting HDDC3's activity by stimulating phosphorylation events that could facilitate its cellular functions. Similarly, Rolipram enhances cAMP levels by inhibiting PDE4, potentially leading to activation of the cAMP-dependent protein kinase A (PKA), which might phosphorylate substrates interacting with HDDC3. The PI3K inhibitor LY294002 may indirectly activate HDDC3 by altering the phosphorylation landscape within the PI3K/Akt pathway, affecting proteins that regulate or interact with HDDC3. Zaprinast, by inhibiting PDE5, raises cGMP levels, which could indirectly enhance the activity of HDDC3 through cGMP-dependent signaling pathways.
Furthermore, the activity of HDDC3 can be indirectly influenced by compounds that affect intracellular calcium levels and phosphorylation states. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium levels, potentially activating calcium-dependent signaling pathways that enhance HDDC3 activity. Okadaic Acid inhibits protein phosphatases, leading to increased phosphorylation within the cell which may prevent dephosphorylation of proteins in pathways involving HDDC3, thereby indirectly enhancing its functional interactions. Phorbol 12-myristate 13-acetate (PMA) activates PKC, leading to downstream phosphorylation events that could activate HDDC3 if it is regulated by PKC-mediated pathways. The polyphenol EGCG might also play a role in indirectly enhancing HDDC3 activity by inhibiting kinases that negatively regulate pathways in which HDDC3 functions. Lastly, SB203580 and U0126 modulate MAPK signaling by inhibiting p38 and MEK1/2, respectively, which might shift signaling equilibria and indirectly enhance HDDC3's role in alternative pathways that become more active when these kinases are inhibited. Collectively, these diverse HDDC3 Activators work through intricate cellular mechanisms to enhance the functional activity of HDDC3 without directly affecting its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular levels of cAMP. The rise in cAMP may indirectly enhance the activity of HDDC3 by promoting phosphorylation events that could facilitate its functional interactions in the cell. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation within the cell. This may indirectly activate HDDC3 by preventing dephosphorylation of proteins in pathways where HDDC3 is involved, possibly enhancing its protein-protein interactions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to downstream phosphorylation events that might enhance HDDC3 activity if HDDC3 is part of a pathway regulated by PKC. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, increasing intracellular calcium levels, which can activate calcium-dependent signaling pathways. This elevation in calcium may indirectly activate HDDC3 by modulating signaling cascades that HDDC3 is a part of. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels via activation of adenylyl cyclase, potentially enhancing HDDC3 activity by promoting cAMP-dependent phosphorylation events. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels in the cell. The raised cAMP may indirectly activate HDDC3 by stimulating cAMP-dependent protein kinase A (PKA), which could phosphorylate substrates relevant to HDDC3's function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to altered phosphorylation patterns in the PI3K/Akt pathway. This may indirectly enhance HDDC3's activity by affecting downstream signaling proteins that interact with or regulate HDDC3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit various protein kinases and has been shown to alter signaling pathways. This might indirectly enhance HDDC3 activity through inhibition of kinases that negatively regulate pathways involving HDDC3. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, which may shift signaling dynamics in the cell, potentially enhancing the activity of HDDC3 if it is associated with alternative pathways that become more prominent when p38 MAPK is inhibited. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5 (PDE5), leading to increased cGMP levels in the cell. Elevated cGMP may indirectly enhance HDDC3 activity through cGMP-dependent protein kinases or signaling pathways that HDDC3 is part of. | ||||||