Date published: 2025-9-14

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HDC Inhibitors

The inhibitors listed here predominantly target histamine-related processes rather than directly inhibiting HDC. However, Alpha-Fluoromethylhistidine (FMH) stands out as a specific and irreversible inhibitor of HDC, making it a significant compound for directly reducing histamine synthesis. The other compounds, such as Loratadine, Diphenhydramine, Chlorpheniramine, and Doxylamine, are antihistamines that block the action of histamine at its receptors. H2 receptor antagonists like Cimetidine, Famotidine, and Ranitidine are specifically used to reduce gastric acid secretion in conditions like peptic ulcers and gastroesophageal reflux disease (GERD). They work by blocking the action of histamine on the H2 receptors of gastric parietal cells, indirectly influencing the role of histamine produced by HDC in the stomach. Proton pump inhibitors (PPIs) like Omeprazole also impact gastric acid secretion but through a different mechanism than H2 antagonists. While PPIs do not directly inhibit HDC, they reduce the stomach's overall acid production, which is partially regulated by histamine. Azelastine and Ketotifen, in addition to their antihistamine properties, have additional actions such as mast cell stabilization, which can further reduce histamine release and its effects.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

4-Bromo-3-hydroxybenzoic acid

14348-38-0sc-261801
sc-261801A
1 g
5 g
$122.00
$273.00
(0)

4-Bromo-3-hydroxybenzoic acid exhibits intriguing properties as a halogenated aromatic compound, characterized by its capacity to form strong hydrogen bonds due to the hydroxyl group. This interaction can influence solubility and reactivity in various solvents. The presence of the bromine atom enhances electrophilicity, facilitating nucleophilic attack in substitution reactions. Additionally, its unique electronic structure allows for selective interactions with metal catalysts, potentially altering reaction pathways and kinetics in organic synthesis.

Loratadine

79794-75-5sc-203117
sc-203117A
10 mg
50 mg
$107.00
$455.00
1
(1)

Loratadine, an antihistamine, does not inhibit HDC directly but can reduce the effects of histamine in the body.

Cimetidine

51481-61-9sc-202996
sc-202996A
5 g
10 g
$62.00
$86.00
1
(1)

Cimetidine, a histamine H2 receptor antagonist, indirectly affects histamine's action, particularly in gastric acid secretion.

Famotidine

76824-35-6sc-205691
sc-205691A
500 mg
1 g
$64.00
$109.00
(0)

Famotidine is another H2 receptor antagonist, reducing the effects of histamine produced by HDC in gastric acid secretion.

Ranitidine

66357-35-5sc-203679
1 g
$189.00
(1)

Ranitidine, similar to Cimetidine and Famotidine, is an H2 antagonist, indirectly affecting histamine-related processes.

Omeprazole

73590-58-6sc-202265
50 mg
$66.00
4
(1)

Omeprazole, a proton pump inhibitor, indirectly impacts histamine's role in gastric acid secretion but does not inhibit HDC.

Diphenhydramine hydrochloride

147-24-0sc-204729
sc-204729A
sc-204729B
10 g
25 g
100 g
$51.00
$82.00
$122.00
4
(1)

Diphenhydramine, an antihistamine, targets histamine receptors but does not directly inhibit HDC.

Chlorpheniramine Maleate

113-92-8sc-204684
sc-204684A
5 g
25 g
$42.00
$97.00
1
(1)

Chlorpheniramine, another antihistamine, alleviates symptoms caused by histamine but does not inhibit HDC.

Azelastine

58581-89-8sc-337544
sc-337544A
sc-337544B
100 mg
500 mg
1 g
$220.00
$550.00
$700.00
(0)

Azelastine, an antihistamine and mast cell stabilizer, affects histamine action without directly inhibiting HDC.

Ketotifen fumarate

34580-14-8sc-201094A
sc-201094
100 mg
1 g
$45.00
$72.00
3
(1)

Ketotifen, which has antihistamine properties, does not directly inhibit HDC but impacts histamine-mediated pathways.