Molecular structure of Loratadine, CAS Number: 79794-75-5
Loratadine (CAS 79794-75-5)
See product citations (1)
Application:
Loratadine is a peripheral histamine H1 receptor agonist
CAS Number:
79794-75-5
Purity:
>99%
Molecular Weight:
382.88
Molecular Formula:
C22H23ClN2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist (IC50 > 32 μM).
Loratadine (CAS 79794-75-5) References
- Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice. | Parkinson, A., et al. 1992. Biochem Pharmacol. 43: 2169-80. PMID: 1534660
- Histamine helps development of eczematous lesions in experimental contact dermatitis in mice. | Seike, M., et al. 2005. Arch Dermatol Res. 297: 68-74. PMID: 15902480
- Metabolism and excretion of loratadine in male and female mice, rats and monkeys. | Ramanathan, R., et al. 2005. Xenobiotica. 35: 155-89. PMID: 16019945
- Association of T-cell receptor Vbeta haplotypes with dry skin in DS-Nh mice. | Imura, K., et al. 2009. Clin Exp Dermatol. 34: 61-7. PMID: 19018787
- CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action. | Schlosburg, JE., et al. 2011. Psychopharmacology (Berl). 216: 323-31. PMID: 21340468
- Antiallergic activity of loratadine, a non-sedating antihistamine. | Kreutner, W., et al. 1987. Allergy. 42: 57-63. PMID: 2436504
- Immunoregulatory effects of the traditional Dai prescription Yajieshaba on food allergic mice. | Zhang, G., et al. 2017. Exp Ther Med. 13: 3175-3182. PMID: 28587391
- Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. | Ahn, HS. and Barnett, A. 1986. Eur J Pharmacol. 127: 153-5. PMID: 2875889
- Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. 1984. | Barnett, A., et al. 1994. Agents Actions. 43: 149-56; discussion 157. PMID: 7725966
- Causal prophylactic activity of antihistaminic agents against Plasmodium yoelii nigeriensis infection in Swiss mice. | Singh, N. and Puri, SK. 1998. Acta Trop. 69: 255-60. PMID: 9638277
Inhibitor of:
CysLT1 Receptor, HDC, and Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Loratadine, 10 mg | sc-203117 | 10 mg | $107.00 | |||
Loratadine, 50 mg | sc-203117A | 50 mg | $455.00 |