HCC-4 Activators
HCC-4 activators constitute a distinct group of chemical compounds that can indirectly augment the function or expression of the HCC-4 chemokine. These chemicals primarily target specific biochemical pathways or cellular processes, whose modulation can emphasize the role of HCC-4. For example, PMA, known for its activation of Protein Kinase C (PKC), can initiate a cascade of downstream signaling events. This cascade has the to result in the heightened production of various chemokines, including HCC-4. Similarly, substances like LPS, known for its pivotal role in activating the NF-kB pathway, can boost the production of cytokines and chemokines, presenting a plausible route for HCC-4 upregulation.
In a broader context, these chemicals shed light on the intricate and interconnected nature of immune regulation. For instance, Anisomycin's role as a JNK activator underscores the JNK pathway's importance in inflammatory gene expression, which can influence the induction of chemokines like HCC-4. Similarly, Bay 11-7082, despite its effects on the NF-kB pathway, demonstrates how the complex interplay of cellular signaling can occasionally produce compensatory responses, leading to the overexpression of immune genes. The diverse nature of these chemicals, from calcium ionophores like A23187 to eicosanoid precursors like Arachidonic Acid, further emphasizes the myriad ways in which cellular systems can be fine-tuned, influencing the levels and roles of chemokines such as HCC-4.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC). PKC activation can lead to a series of downstream signaling events, which may culminate in the upregulation of several chemokines, potentially including HCC-4. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore, A23187 elevates intracellular calcium levels. Elevated calcium levels can activate various signaling pathways leading to the expression of immune-responsive genes, potentially affecting HCC-4 production. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator. The JNK pathway plays a role in the expression of inflammatory genes, and its activation might lead to the induction of chemokines such as HCC-4. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS activates the NF-kB pathway, a critical pathway for the production of various cytokines and chemokines. This activation can lead to an upregulation of chemokines, potentially including HCC-4. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An inhibitor of the NF-kB pathway, Bay 11-7082 might seem counterintuitive. However, in certain contexts, its application can lead to a compensatory overexpression of certain immune genes, potentially including HCC-4. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Rottlerin is a PKC delta inhibitor. In certain immune cells, PKC delta inhibits pro-inflammatory responses, so its inhibition by rottlerin could potentially boost the expression of chemokines, including HCC-4. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid is a precursor for eicosanoids. These lipid mediators can influence the immune response, potentially leading to the modulation of chemokines including HCC-4. | ||||||
Zymosan | 9010-72-4 | sc-296863 sc-296863A | 100 mg 1 g | $99.00 $599.00 | 1 | |
A fungal product, Zymosan activates immune cells via TLR2 and Dectin-1. This activation can stimulate various immune responses, potentially leading to an upregulation of chemokines, including HCC-4. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
A synthetic analog of double-stranded RNA, Poly(I:C) activates TLR3. This activation can lead to immune cell stimulation and the subsequent potential production of chemokines, including HCC-4. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
A synthetic triacylated lipopeptide, Pam3CSK4 activates TLR1/TLR2. Such activation can result in the induction of various immune responses, possibly leading to the expression of chemokines such as HCC-4. | ||||||