Haspin Activators
Haspin activators are a class of chemicals that can indirectly stimulate the activity of Haspin kinase, a protein involved in the correct segregation of chromosomes during mitosis. These chemicals primarily exert their effects through the disruption of various cellular processes, including DNA replication and repair, and microtubule dynamics, thereby inducing cell cycle arrest, particularly at the G2/M phase or M phase.
Chemicals such as Paclitaxel, Nocodazole, Colchicine, Vinblastine, and Vincristine interfere with microtubule dynamics, thus leading to mitotic errors and indirectly stimulating Haspin kinase activity as part of the cell's response to these errors. On the other hand, Camptothecin, Doxorubicin, Etoposide, Bleomycin, Cisplatin, Carboplatin, and Oxaliplatin cause DNA damage and induce cell cycle arrest at the G2/M phase. As the cells attempt to repair the damage and proceed through mitosis, this can lead to an increase in Haspin kinase activity. It should be noted that while these chemicals can indirectly influence Haspin activity, they also affect a wide array of other cellular processes and their use can lead to broad cellular effects beyond the modulation of Haspin.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol is a microtubule stabilizer that promotes microtubule polymerization. By disrupting microtubule dynamics, it can induce a mitotic arrest, which in turn can increase Haspin kinase activity as part of the cell's response to mitotic errors. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor, leading to DNA damage and subsequently causing cell cycle arrest at the G2/M phase. This situation can increase the activity of Haspin as cells attempt to enter mitosis. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and inhibits topoisomerase II, leading to DNA damage and cell cycle arrest. This can indirectly increase Haspin activity as cells are stalled at the G2/M phase and attempt to enter mitosis. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II, leading to DNA damage and subsequent cell cycle arrest at G2/M phase. This can indirectly stimulate Haspin activity as cells try to proceed through mitosis. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that causes cell cycle arrest in the M phase by disrupting microtubule dynamics. This can indirectly stimulate Haspin kinase activity as part of the cell's response to mitotic errors. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, disrupting the formation of microtubules. This leads to cell cycle arrest at the M phase, which can indirectly stimulate Haspin kinase activity as the cell tries to repair mitotic errors. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine is a microtubule-depolymerizing agent that leads to M phase arrest by disrupting microtubule dynamics. This can indirectly stimulate Haspin kinase activity as part of the cell's response to mitotic errors. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin is a DNA damaging agent that causes cell cycle arrest at various points, including G2/M. This can indirectly stimulate Haspin activity as cells try to proceed through mitosis. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms intra-strand and inter-strand crosslinks in DNA, leading to DNA damage and subsequent cell cycle arrest at G2/M phase. This can indirectly stimulate Haspin activity as cells attempt to enter mitosis. | ||||||
Carboplatin | 41575-94-4 | sc-202093 sc-202093A | 25 mg 100 mg | $47.00 $132.00 | 14 | |
Carboplatin is a DNA crosslinking agent that causes DNA damage and cell cycle arrest at G2/M phase. This can indirectly stimulate Haspin activity as cells try to proceed through mitosis. | ||||||