Molecular structure of Carboplatin, CAS Number: 41575-94-4
Carboplatin (CAS 41575-94-4)
See product citations (14)
Alternate Names:
cis-Diammine [1,1-cyclobutanedicarboxylato] platinum (II)
Application:
Carboplatin is an antitumor agent that binds to DNA leading to apoptosis
CAS Number:
41575-94-4
Purity:
>98%
Molecular Weight:
371.25
Molecular Formula:
C6H12N2O4Pt
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Carboplatin is a second generation potent platinum-based antineoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, cisplatin (sc-200896), the first of this class of antineoplastic agents. Carboplatin displays potent antitumor activity and lower nephrotoxicity than cisplatin (sc-200896). The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.
Carboplatin (CAS 41575-94-4) References
- Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin. | Go, RS. and Adjei, AA. 1999. J Clin Oncol. 17: 409-22. PMID: 10458260
- What is the 'best' platinum: cisplatin, carboplatin, or oxaliplatin? | Lokich, J. 2001. Cancer Invest. 19: 756-60. PMID: 11577818
- Simple and rapid determination of carboplatin in plasma by high-performance liquid chromatography. Error pattern and application to clinical pharmacokinetic studies. | Zufía, L., et al. 2001. J Chromatogr B Biomed Sci Appl. 764: 457-64. PMID: 11817042
- Carboplatin in combination therapy for metastatic breast cancer. | Perez, EA. 2004. Oncologist. 9: 518-27. PMID: 15477636
- [Level of evidence for therapeutic drug monitoring of carboplatin]. | Hulin, A., et al. 2010. Therapie. 65: 157-62. PMID: 20699065
- Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. | Hall, MD., et al. 2014. Cancer Res. 74: 3913-22. PMID: 24812268
- Carboplatin hypersensitivity: evaluation and successful desensitization protocol. | Bruchim, I., et al. 2014. Immunotherapy. 6: 905-12. PMID: 25313569
- Pharmacokinetics of Carboplatin in a One-Year-Old Anuric Boy Undergoing Hemodialysis and a Review of the Literature. | Kamei, K., et al. 2015. Ther Apher Dial. 19: 491-6. PMID: 25916242
- Cisplatin versus carboplatin: comparative review of therapeutic management in solid malignancies. | Ho, GY., et al. 2016. Crit Rev Oncol Hematol. 102: 37-46. PMID: 27105947
- Carboplatin: a very active new cisplatin analog in the treatment of small cell lung cancer. | Smith, IE., et al. 1985. Cancer Treat Rep. 69: 43-6. PMID: 2981620
- Carboplatin (JM8) as a single agent and in combination in the treatment of small cell lung cancer. | Smith, IE. and Evans, BD. 1985. Cancer Treat Rev. 12 Suppl A: 73-5. PMID: 3002624
- The Inhibitory Effect of Carboplatin Injection on Human Neuroblastoma SK-N-SH. | Xu, J., et al. 2020. Cell Transplant. 29: 963689720920815. PMID: 32659114
- Reassessment of the Efficacy of Carboplatin for Metastatic Urothelial Carcinoma in the Era of Immunotherapy: A Systematic Review and Meta-analysis. | Mori, K., et al. 2022. Eur Urol Focus. 8: 1687-1695. PMID: 35279408
- Pharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) in patients with normal and impaired renal function. | Harland, SJ., et al. 1984. Cancer Res. 44: 1693-7. PMID: 6367971
Inhibitor of:
4930432K21Rik, AChRα, Acid Ceramidase, APOBEC2, BRCA2, BRCC3, C11orf82, Collagen Type IV, DNA pol η, INPP5E, KIN17, p53R2, PMS1, PRPF4, RuvC, Slfn11, SNM1A, TDE1, TDP2, TMC2, and V1RH17.Activator of:
DNA pol ε A, DnaJA2, ERCC1, GTBP, Haspin, LRWD1, Melanoma Marker, MRE11_Mre11, MRP1, PGBD5, SSX4, and ZNF234.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carboplatin, 25 mg | sc-202093 | 25 mg | $47.00 | |||
Carboplatin, 100 mg | sc-202093A | 100 mg | $132.00 |