HACS1 Activators
HACS1, an acronym for Hematopoietic Adaptor-Containing Src Homology 2 (SH2) Domain 1, is a protein encoded by the HACS1 gene in humans. It is a relatively less studied member of the family of SH2 domain-containing proteins, which are known for their critical roles in cellular signaling pathways.HACS1 is predominantly expressed in hematopoietic cells, including various types of immune cells like B cells, T cells, and macrophages. Its expression is particularly notable in B cells, suggesting a significant role in the immune system, particularly in adaptive immunity.
The SH2 domain of HACS1 is instrumental for its function. SH2 domains are known for their ability to bind phosphotyrosine residues, which are common in activated receptor tyrosine kinases and other signaling molecules. Through this interaction, HACS1 likely participates in signaling pathways that regulate immune cell function, proliferation, and differentiation.Research indicates that HACS1 might be involved in the regulation of immune responses and hematopoiesis (the production of blood cells). It may play a role in the signal transduction pathways initiated by receptors on the surface of immune cells, influencing their responses to external stimuli.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various signaling pathways that could intersect with HACS1-related pathways. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, potentially affecting T-cell signaling pathways that intersect with HACS1 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and proliferation, which may indirectly influence HACS1 activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases, which may influence signaling pathways relevant to HACS1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, potentially affecting pathways that intersect with HACS1 activity. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-kappaB activation, potentially affecting signaling pathways that intersect with HACS1 functions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK Inhibitor II selectively inhibits c-Jun N-terminal kinase, which may influence signaling pathways relevant to HACS1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, potentially impacting pathways that intersect with HACS1 activity. | ||||||
Imatinib mesylate | 220127-57-1 | sc-202180 sc-202180A | 25 mg 100 mg | $45.00 $111.00 | 61 | |
Imatinib Mesylate is a tyrosine kinase inhibitor, which could affect signaling pathways relevant to HACS1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, which could impact signaling pathways relevant to HACS1. | ||||||