Date published: 2026-4-14

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H6PD Inhibitors

H6PD inhibitors form a chemical class of compounds specifically designed to selectively and reversibly target Hexose-6-phosphate dehydrogenase (H6PD), an enzyme involved in the metabolism of glucose and other sugars. These inhibitors are carefully engineered to interact with H6PD, modulating its enzymatic activity and its role in glucose metabolism. The chemical structure of H6PD inhibitors allows them to bind to specific regions or binding sites on the enzyme, interfering with its ability to catalyze the conversion of hexose-6-phosphate to its corresponding product. Researchers utilize H6PD inhibitors in biochemical and cellular studies to investigate the functions of H6PD in glucose metabolism and its implications in metabolic regulation. The design and development of these inhibitors are based on a comprehensive understanding of H6PD's structural features and its involvement in sugar metabolism, offering essential tools for advancing research in the field of metabolic biochemistry and cellular energetics.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Piericidin A

2738-64-9sc-202287
2 mg
$291.00
24
(1)

Piericidin A functions as a potent inhibitor of H6PD, exhibiting a unique interaction with the enzyme's active site that disrupts its normal catalytic function. This compound alters the redox state within the cell by modulating the NADP+/NADPH balance, influencing metabolic pathways. Its distinct structural features facilitate specific molecular interactions, leading to altered reaction kinetics and a profound impact on cellular energy dynamics.

STF 31

724741-75-7sc-364692
10 mg
$187.00
3
(1)

A synthetic compound known to inhibit H6PD activity and affect glucose metabolism in certain cellular contexts.

CP-91149

186392-40-5sc-396026A
sc-396026
sc-396026B
sc-396026C
sc-396026D
5 mg
10 mg
25 mg
50 mg
100 mg
$163.00
$204.00
$398.00
$500.00
$714.00
1
(0)

This is a specific inhibitor of H6PD that has been studied for its effects on glucose metabolism and redox regulation.

6-Azauridine

54-25-1sc-221082B
sc-221082
sc-221082C
sc-221082A
500 mg
1 g
2 g
5 g
$97.00
$159.00
$295.00
$679.00
(0)

Azauridine is a pyrimidine analog that has been reported to inhibit H6PD in certain experimental settings.

Carbenoxolone disodium

7421-40-1sc-203868
sc-203868A
sc-203868B
sc-203868C
1 g
5 g
10 g
25 g
$46.00
$201.00
$358.00
$774.00
1
(3)

Originally developed as an antiulcer drug, Carbenoxolone has been shown to inhibit H6PD activity.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

A flavonoid compound found in various plants, Quercetin has been reported to inhibit H6PD and affect glucose metabolism.

2,4,6-Trihydroxybenzoic Acid

83-30-7sc-475886
10 g
$255.00
(0)

A polyphenolic compound known to inhibit H6PD and modulate glucose metabolism.

1,3-Dihydroxyacetone

96-26-4sc-499029
sc-499029A
sc-499029B
sc-499029C
sc-499029D
5 g
50 g
100 g
250 g
500 g
$109.00
$151.00
$234.00
$411.00
$577.00
1
(0)

Dihydroxyacetone, a simple sugar, has been reported to inhibit H6PD in certain experimental conditions.

6-Aminonicotinamide

329-89-5sc-278446
sc-278446A
1 g
5 g
$156.00
$398.00
3
(1)

This compound is an analog of nicotinamide and has been studied for its inhibitory effects on H6PD.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$156.00
$1248.00
$12508.00
82
(1)

Insulin, a hormone involved in glucose metabolism, has been reported to inhibit H6PD activity in certain contexts.