H60b Activators encompass a range of chemical compounds that indirectly enhance the functional activity of H60b, mainly in the context of immune cell signaling and activation. Forskolin, through its activation of adenylate cyclase, leads to an increase in cAMP levels, which in turn activates protein kinase A (PKA). PKA phosphorylates a variety of substrates, thereby potentially augmenting H60b's involvement in immune responses. Similarly, Ionomycin's role as a calcium ionophore boosts intracellular calcium levels, a critical factor for calcium-dependent signaling pathways on which H60b's immune functions may rely. The activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) is another pathway influencing H60b, especially in natural killer (NK) cell activation. Furthermore, the modulation of the MEK/ERK pathway by U0126 and the PI3K/AKT pathway by LY294002 could shift cellular signaling towards pathways that enhance H60b's activity, particularly in NK cell interactions and immune responses.
Continuing this intricate interplay of biochemical pathways, compounds like SB203580, Curcumin, and Sphingosine-1-phosphate (S1P) each contribute uniquely to the activation of H60b. SB203580's inhibition of p38 MAPK potentially upregulates pathways that boost H60b's function in stress-related immune responses, while Curcumin's modulation of NF-κB signaling might enhance H60b's role in NK cell-mediated cytotoxicity. S1P, through its receptor-mediated signaling, can also support H60b's function in immune surveillance. Additionally, Thapsigargin's ability to elevate intracellular calcium levels might indirectly augment H60b's role in immune cell activation. Resveratrol and Epigallocatechin gallate (EGCG) influence various signaling pathways, including those related to stress and inflammation, thereby potentially enhancing H60b's activity in immune regulation. Lastly, Genistein, as a tyrosine kinase inhibitor, may facilitate the activation of H60b, particularly in NK cell-mediated immune responses, by reducing competition from tyrosine kinase signaling pathways. These diverse chemical compounds collectively enhance the functional activity of H60b through their targeted effects on various signaling pathways, crucially without necessitating direct interaction with H60b itself.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. This elevation activates PKA, potentially enhancing H60b's role in immune cell signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Acts as a calcium ionophore, raising intracellular calcium levels, which may activate calcium-dependent pathways, enhancing H60b's role in immune responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), leading to phosphorylation in immune signaling, possibly augmenting H60b's function in NK cell activation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK, potentially shifting cellular signaling to enhance H60b's activity in immune cell interactions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor affecting downstream AKT signaling, possibly enhancing H60b-mediated signaling in NK cell activation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAPK, potentially enhancing signaling pathways that upregulate H60b activity, especially in stress-related immune responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Modulates multiple pathways including NF-κB, potentially enhancing H60b's function in NK cell-mediated cytotoxicity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Through its receptors, modulates signaling pathways, potentially enhancing H60b's role in immune surveillance and NK cell activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Elevates intracellular calcium levels, potentially enhancing calcium-dependent pathways and H60b's role in immune cell activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Influences various signaling pathways, including SIRT1 activation, which might enhance H60b's activity in immune regulation and NK cell function. |