Date published: 2025-9-11

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H60b Activators

H60b Activators encompass a range of chemical compounds that indirectly enhance the functional activity of H60b, mainly in the context of immune cell signaling and activation. Forskolin, through its activation of adenylate cyclase, leads to an increase in cAMP levels, which in turn activates protein kinase A (PKA). PKA phosphorylates a variety of substrates, thereby potentially augmenting H60b's involvement in immune responses. Similarly, Ionomycin's role as a calcium ionophore boosts intracellular calcium levels, a critical factor for calcium-dependent signaling pathways on which H60b's immune functions may rely. The activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) is another pathway influencing H60b, especially in natural killer (NK) cell activation. Furthermore, the modulation of the MEK/ERK pathway by U0126 and the PI3K/AKT pathway by LY294002 could shift cellular signaling towards pathways that enhance H60b's activity, particularly in NK cell interactions and immune responses.

Continuing this intricate interplay of biochemical pathways, compounds like SB203580, Curcumin, and Sphingosine-1-phosphate (S1P) each contribute uniquely to the activation of H60b. SB203580's inhibition of p38 MAPK potentially upregulates pathways that boost H60b's function in stress-related immune responses, while Curcumin's modulation of NF-κB signaling might enhance H60b's role in NK cell-mediated cytotoxicity. S1P, through its receptor-mediated signaling, can also support H60b's function in immune surveillance. Additionally, Thapsigargin's ability to elevate intracellular calcium levels might indirectly augment H60b's role in immune cell activation. Resveratrol and Epigallocatechin gallate (EGCG) influence various signaling pathways, including those related to stress and inflammation, thereby potentially enhancing H60b's activity in immune regulation. Lastly, Genistein, as a tyrosine kinase inhibitor, may facilitate the activation of H60b, particularly in NK cell-mediated immune responses, by reducing competition from tyrosine kinase signaling pathways. These diverse chemical compounds collectively enhance the functional activity of H60b through their targeted effects on various signaling pathways, crucially without necessitating direct interaction with H60b itself.

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Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Activates adenylate cyclase, increasing cAMP levels. This elevation activates PKA, potentially enhancing H60b's role in immune cell signaling.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Acts as a calcium ionophore, raising intracellular calcium levels, which may activate calcium-dependent pathways, enhancing H60b's role in immune responses.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

Activates protein kinase C (PKC), leading to phosphorylation in immune signaling, possibly augmenting H60b's function in NK cell activation.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

Inhibits MEK, potentially shifting cellular signaling to enhance H60b's activity in immune cell interactions.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

PI3K inhibitor affecting downstream AKT signaling, possibly enhancing H60b-mediated signaling in NK cell activation.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

Inhibits p38 MAPK, potentially enhancing signaling pathways that upregulate H60b activity, especially in stress-related immune responses.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Modulates multiple pathways including NF-κB, potentially enhancing H60b's function in NK cell-mediated cytotoxicity.

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

Through its receptors, modulates signaling pathways, potentially enhancing H60b's role in immune surveillance and NK cell activation.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Elevates intracellular calcium levels, potentially enhancing calcium-dependent pathways and H60b's role in immune cell activation.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Influences various signaling pathways, including SIRT1 activation, which might enhance H60b's activity in immune regulation and NK cell function.