H2BFWT Activators
H2BFWT Activators encompass a diverse array of chemical compounds that, through various mechanisms, indirectly enhance the functional activity of the histone protein H2BFWT. Histone deacetylase inhibitors such as Sodium Butyrate increase the acetylation levels of histones, including H2BFWT, leading to a less compact chromatin structure and potentially more active gene expression. DNA methylation modifiers like 5-Azacytidine and RG108 contribute to this process by inhibiting DNA methyltransferases, resulting in a decrease in DNA methylation and a corresponding increase in gene expression which would encompass the activity of H2BFWT. Methyltransferase inhibitors such as Methylstat and BIX-01294 target the methylation of histones, preventing the addition of methyl groups to H2BFWT, which can repress gene expression, and by inhibiting these enzymes, the compounds could indirectly promote a more transcriptionally conducive environment for H2BFWT function.
Furthermore, compounds such as Anacardic Acid and Curcumin, which modulate the activity of histone acetyltransferases, might also lead to alterations in H2BFWT activity by disrupting normal acetylation patterns. Disulfiram, through its chelating effect on copper, inhibits histone demethylases, potentially altering the methylation status of H2BFWT and thus indirectly enhancing its functional activity. Parthenolide's inhibition of the NF-kB pathway suggests a broader impact on signaling pathways that could influence the post-translational modification landscape of H2BFWT. Caffeine, with its known effects on cellular signaling and potential to influence phosphorylation, may also have a role in modifying H2BFWT's function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is incorporated into DNA where it inhibits DNA methyltransferases, leading to hypomethylation of DNA. As DNA methylation can affect chromatin structure and histone modification state, the reduction of methylation can indirectly result in the enhanced activity of H2BFWT by promoting a more transcriptionally active chromatin state. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, which can lead to hyperacetylation of histones, including H2BFWT. This hyperacetylation typically correlates with an open chromatin conformation and can therefore indirectly enhance the functional activity of H2BFWT. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
Methylstat is a histone methyltransferase inhibitor which can prevent methylation on histones including H2BFWT. Since histone methylation can lead to either activation or repression of transcription, depending on the specific site and state of methylation, inhibition by Methylstat could lead to an increase in H2BFWT's functional activity in certain contexts. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a histone methyltransferase inhibitor that specifically targets G9a and GLP, which methylate histone H3. By inhibiting these enzymes, BIX-01294 can indirectly affect the methylation state of H2BFWT and potentially enhance its functional activity by altering chromatin structure. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor which prevents DNA methylation, this can result in a more open chromatin configuration which may subsequently increase the functional activity of histone proteins like H2BFWT. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic Acid inhibits histone acetyltransferase enzymes, which can affect the acetylation status of histones, including H2BFWT. Although primarily an inhibitor, it may indirectly enhance H2BFWT functional activity by disrupting normal acetylation patterns and altering gene expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is known to indirectly affect many cellular processes, including the phosphorylation of certain proteins. As phosphorylation can alter histone function, caffeine may influence the functional activity of H2BFWT indirectly through these mechanisms. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has various cellular effects, including inhibition of histone acetyltransferase, which can alter the acetylation pattern of H2BFWT. By changing the chromatin structure, curcumin may indirectly enhance the functional activity of H2BFWT. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate copper, leading to the inhibition of the Jumonji family of histone demethylases. This could indirectly enhance the functional activity of H2BFWT by affecting chromatin architecture and gene expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide has been shown to inhibit the NF-kB pathway and may also affect other signaling pathways that modulate the post-translational modification of histones like H2BFWT, potentially enhancing their functional activity indirectly. | ||||||