GW182 Inhibitors
GW182 inhibitors are a class of chemical compounds that primarily target a protein known as GW182. These inhibitors have garnered significant attention in the field of molecular biology and biochemistry due to their role in the regulation of gene expression and cellular processes. GW182 is a crucial component of the RNA-induced silencing complex (RISC), which plays a central role in RNA interference (RNAi) pathways in eukaryotic organisms. In RNAi, small RNA molecules guide RISC to target messenger RNAs (mRNAs) for degradation or translational repression, effectively silencing the expression of specific genes. GW182 inhibitors are designed to interfere with this process by binding to GW182 and disrupting its interactions with other components of the RISC complex, ultimately impairing the RNAi machinery's ability to carry out gene silencing.
The chemical structures and mechanisms of GW182 inhibitors can vary, but their common goal is to impede the function of GW182 in post-transcriptional gene regulation. By doing so, these inhibitors provide valuable tools for researchers studying the intricacies of gene expression and the role of RNAi in cellular processes. Furthermore, their use in laboratory settings allows scientists to explore the consequences of inhibiting GW182, shedding light on its broader functions and implications for basic biological research
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and inhibits RNA polymerase, potentially reducing the transcription of the GW182 gene and subsequently decreasing its protein expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
As a pyrimidine analog, 5-Fluorouracil incorporates into RNA, potentially causing aberrant transcription and translation processes that could decrease GW182 protein levels. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis in eukaryotic organisms, which could lead to a general decrease in protein levels, including GW182. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which plays a crucial role in protein synthesis. Inhibition of this pathway could result in reduced GW182 protein expression. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA and inhibits topoisomerase II, potentially disrupting normal transcription and translation processes and decreasing GW182 protein levels. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide stabilizes the DNA-topoisomerase II complex, causing DNA damage and potentially decreasing the transcription and translation of GW182. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, potentially leading to DNA damage and a decrease in GW182 protein expression through disrupted transcription and translation processes. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is a folate analog that inhibits dihydrofolate reductase, potentially leading to decreased nucleotide synthesis and reduced transcription of the GW182 gene. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine raises endosomal pH, potentially affecting cellular processes and mRNA stability, which could result in decreased GW182 protein levels. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Emetine inhibits protein synthesis at the level of translation elongation, potentially leading to a decrease in GW182 protein levels. | ||||||