GTPBP10 Inhibitors
GTPBP10 inhibitors constitute a specialized class of chemical compounds designed to specifically target and impede the function of the GTPBP10 protein, a GTP-binding protein associated with various cellular processes, including ribosome biogenesis and mRNA surveillance. The action of these inhibitors is predicated on their ability to bind to the active sites or allosteric sites of GTPBP10, effectively blocking its GTPase activity. By preventing the hydrolysis of GTP to GDP, these inhibitors halt the necessary conformational changes of the GTPBP10 protein that are essential for its function. The intricate mechanisms of inhibition are diverse among the different molecules within this class, each uniquely tailored to interact with the protein's structure. For example, some inhibitors may mimic the structure of GTP, competitively occupying the binding site and thus preventing proper substrate access. Others might bind to regions of the protein that are crucial for its stability or interaction with other molecular partners, thereby causing a reduction in its activity through an indirect allosteric mechanism.
The development of GTPBP10 inhibitors is grounded on an in-depth understanding of the protein's role at the molecular level. These compounds are characterized by their ability to disrupt the normal biological processes in which GTPBP10 is a participant, leading to a downstream effect on protein synthesis and cell cycle regulation. The specificity of these inhibitors is crucial, as they must selectively target GTPBP10 without affecting the plethora of other GTPases within the cell, maintaining a high degree of selectivity to avoid off-target effects that could disrupt cellular homeostasis. Through their targeted action, GTPBP10 inhibitors affect the protein's interactions and its ability to bind to ribosomal and messenger RNA substrates, which is central to its role in monitoring and ensuring the fidelity of protein translation. The interference with these fundamental processes delineates how the inhibitors can lead to a decrease in the functional activity of GTPBP10, affirming their efficacy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A, a macrolide antibiotic, inhibits mitochondrial ATP synthase. GTPBP10, associated with mitochondrial ribosome biogenesis, would have reduced functionality due to decreased ATP levels, impacting the energy-dependent steps of ribosome assembly. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol is a bacterial protein synthesis inhibitor that binds to the 50S ribosomal subunit. It can indirectly affect GTPBP10 by limiting mitochondrial protein synthesis, which is essential for mitochondrial function and, consequently, for GTPBP10's role in mitochondrial ribosome biogenesis. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $160.00 $319.00 | 3 | |
Actinonin is a peptide antibiotic that inhibits aminopeptidase P and methionine aminopeptidase 2, enzymes involved in protein processing. Since GTPBP10 is linked to protein synthesis, actinonin's inhibition of protein maturation would indirectly impair GTPBP10 function. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline binds to the 30S subunit of bacterial ribosomes, inhibiting protein synthesis. This antibiotic could also influence mitochondrial protein synthesis, thereby decreasing the function of GTPBP10 in mitochondrial ribosome assembly. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Doxycycline, a tetracycline antibiotic, inhibits mitochondrial protein synthesis by binding to the ribosomal 30S subunit, which can indirectly reduce GTPBP10 function due to its role in mitochondrial ribosome assembly. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by targeting the 80S ribosome. This inhibition can indirectly affect GTPBP10's role in the assembly of mitochondrial ribosomes as protein synthesis is a key component of this process. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Puromycin causes premature chain termination during protein synthesis by acting like an aminoacyl-tRNA analog. This leads to the inhibition of mitochondrial protein synthesis interfering with GTPBP10's function in mitochondrial ribosome biogenesis. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
Zidovudine is a nucleoside analog reverse transcriptase inhibitor that can incorporate into mitochondrial DNA, leading to impaired mtDNA synthesis. This impairment would indirectly inhibit GTPBP10 activity, as mtDNA encodes components vital for mitochondrial ribosome assembly. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $47.00 $147.00 $576.00 $2045.00 | 12 | |
Ethidium Bromide intercalates into DNA, affecting its replication and transcription. It can indirectly inhibit GTPBP10 by disrupting mtDNA replication and thus mitochondrial protein synthesis, which is crucial for GTPBP10's role in ribosome biogenesis. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin inhibits bacterial RNA polymerase and can also inhibit mitochondrial RNA polymerase. This action would reduce mitochondrial RNA synthesis, indirectly affecting GTPBP10 by impairing the synthesis of mitochondrial ribosomal components. | ||||||