GS188 Activators
GS188 Activators function primarily by enhancing the intracellular levels of cyclic adenosine monophosphate (cAMP), a pivotal second messenger in many cellular processes. Forskolin, PGE2, Isoprenaline, Epinephrine, Dopamine, SKF38393, and BRL 37344 increase intracellular cAMP levels by activating adenylate cyclase or specific receptors linked to adenylate cyclase. On the other hand, IBMX, Rolipram, and ZM241385 raise intracellular cAMP levels by inhibiting phosphodiesterase or the A2A adenosine receptor, which normally decreases cAMP levels. The increased cAMP levels stimulate protein kinase A (PKA), which can then activate GS188 by phosphorylating it.
The activation of GS188 by PKA is a vital step in the functional activation of GS188. An increased intracellular cAMP level leads to the activation of PKA. Once activated, PKA can phosphorylate and activate GS188, thereby enhancing its functional activity. 8-Bromo-cAMP directly activates PKA, thus bypassing the need for increased cAMP levels. H-89, in contrast, functions by inhibiting PKA. This inhibition can reduce the negative feedback on GS188, thereby enhancing its activity. Therefore, the functional activation of GS188 can be achieved through various biochemical strategies, either by increasing cAMP levels or directly stimulating PKA.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases intracellular cAMP levels. The rise in cAMP levels can stimulate PKA, which in turn can activate GS188 by phosphorylation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. The activation of PKA can lead to the phosphorylation and activation of GS188. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a PKA inhibitor. By inhibiting PKA, it can reduce the negative feedback inhibition on GS188, thereby increasing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a phosphodiesterase inhibitor that increases intracellular cAMP levels. Elevated cAMP can stimulate PKA, which then activates GS188 by phosphorylation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a phosphodiesterase inhibitor that increases intracellular cAMP levels. Elevated cAMP can stimulate PKA, which then activates GS188 by phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 is a prostaglandin that activates adenylate cyclase, which increases cAMP levels. Elevated cAMP can stimulate PKA, which then activates GS188 by phosphorylation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoprenaline is a beta-adrenergic receptor agonist that increases cAMP levels. Elevated cAMP can stimulate PKA, which then activates GS188 by phosphorylation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is a beta-adrenergic receptor agonist that increases cAMP levels. Elevated cAMP can stimulate PKA, which then activates GS188 by phosphorylation. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a D1-like receptor agonist that increases cAMP levels. Elevated cAMP can stimulate PKA, which then activates GS188 by phosphorylation. | ||||||
SKF 38393 hydrochloride | 62717-42-4 | sc-203264 | 25 mg | $50.00 | ||
SKF38393 is a D1-like receptor agonist that increases cAMP levels. Elevated cAMP can stimulate PKA, which then activates GS188 by phosphorylation. | ||||||