Molecular structure of SKF 38393 hydrochloride, CAS Number: 62717-42-4
SKF 38393 hydrochloride (CAS 62717-42-4)
Alternate Names:
(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8- diol hydrobromide
Application:
SKF 38393 hydrochloride is a benzazepine selective agonist of D1DR
CAS Number:
62717-42-4
Purity:
≥97%
Molecular Weight:
291.77
Molecular Formula:
C16H17NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR.
SKF 38393 hydrochloride (CAS 62717-42-4) References
- SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. | Muralikrishnan, D. and Ebadi, M. 2001. Brain Res. 892: 241-7. PMID: 11172770
- Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine. | Katz, JL. and Witkin, JM. 1992. Psychopharmacology (Berl). 107: 217-20. PMID: 1352052
- Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. | Briggs, CA., et al. 1991. Br J Pharmacol. 104: 1038-44. PMID: 1687364
- Neurophysiological investigation of effects of the D-1 agonist SKF 38393 on tonic activity of substantia nigra dopamine neurons. | Carlson, JH., et al. 1987. Synapse. 1: 411-6. PMID: 2975067
- Stimulation of dopamine D-1 receptors by SKF 38393 induces EEG desynchronization and behavioral arousal. | Ongini, E., et al. 1985. Life Sci. 37: 2327-33. PMID: 3877855
- Evidence for heterogeneous rotational responsiveness to apomorphine, 3-PPP and SKF 38393 in 6-hydroxydopamine-denervated rats. | Fenton, HM., et al. 1984. Eur J Pharmacol. 106: 363-72. PMID: 6442233
- Dopamine D1 receptor-stimulated release of acetylcholine in rat striatum is mediated indirectly by activation of striatal neurokinin1 receptors. | Anderson, JJ., et al. 1994. J Pharmacol Exp Ther. 269: 1144-51. PMID: 7912277
- Neonatal 6-hydroxydopamine and adult SKF 38393 treatments alter dopamine D1 receptor mRNA levels: absence of other neurochemical associations with the enhanced behavioral responses of lesioned rats. | Gong, L., et al. 1994. J Neurochem. 63: 1282-90. PMID: 7931280
- Dose-related effects of a neonatal 6-OHDA lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. | Gong, L., et al. 1993. Brain Res Dev Brain Res. 76: 233-8. PMID: 8149589
- Ontogenetic SKF 38393 treatments sensitize dopamine D1 receptors in neonatal 6-OHDA-lesioned rats. | Gong, L., et al. 1993. Brain Res Dev Brain Res. 76: 59-65. PMID: 8306431
- Age-dependence of a 6-hydroxydopamine lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. | Kostrzewa, RM., et al. 1993. Brain Res Dev Brain Res. 76: 87-93. PMID: 8306435
- Dopamine enhances glutamate-induced excitation of rat striatal neurons by cooperative activation of D1 and D2 class receptors. | Hu, XT. and White, FJ. 1997. Neurosci Lett. 224: 61-5. PMID: 9132692
- Attenuation of oxidative neuronal necrosis by a dopamine D1 agonist in mouse cortical cell cultures. | Noh, JS. and Gwag, BJ. 1997. Exp Neurol. 146: 604-8. PMID: 9270075
Inhibitor of:
TH.Activator of:
D1DR, D2DR, D5DR, DARPP-32, GALP, GRIN3, GS188, LOC390937_EG232974, and SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SKF 38393 hydrochloride, 25 mg | sc-203264 | 25 mg | $50.00 |