GS188 Inhibitors
GS188 Inhibitors primarily operate by blocking the signalling pathways that GS188 is directly involved in. This can be achieved by inhibiting protein kinases like PKC and JNK, as well as Src-family kinases, all of which are known to activate GS188. Specific inhibitors for these kinases include Staurosporine, Dasatinib, SP600125, Go6983, Ro-31-8220. By inhibiting these kinases, these chemical compounds can lead to a decrease in the activation of GS188. Additionally, the NF-κB pathway is known to activate GS188, therefore, inhibitors like BAY 11-7082 and BAY 11-7085 that reduces NF-κB activation can lead to decreased activation of GS188.
Furthermore, the MAPK pathway, specifically the MEK component, is known to activate GS188. Therefore, MEK inhibitors like PD98059 and U0126 can decrease GS188 activation. Additionally, the PI3K and mTOR signalling pathways are known to activate GS188, so inhibition of these pathways by LY294002 and Rapamycin, respectively, can lead to decreased activation of GS188. Finally, EGFR is a known activator ofGS188. Therefore, its inhibition by AG 1478 can result in decreased activation of GS188. Hence, through the inhibition of these specific pathways and molecules, the functional activity of GS188 can be reduced.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC which is a crucial mediator in some of the signaling pathways GS188 is involved in. By inhibiting PKC, Staurosporine can lead to a decrease in the activation of GS188. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib inhibits Src-family kinases, which are upstream activators of many proteins including GS188. Inhibition of Src-family kinases by Dasatinib could lead to decreased activation of GS188. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK, a protein kinase that is part of the signaling cascade that activates GS188. Inhibition of JNK by SP600125 can result in decreased activation of GS188. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is a known activator of many proteins, including GS188. Inhibition of PI3K by LY294002 can lead to decreased activation of GS188. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go6983 inhibits PKC, a known activator of GS188. Inhibition of PKC by Go6983 can lead to decreased activation of GS188. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation by blocking the cytokine-induced IκBα phosphorylation. Since NF-κB is a known activator of GS188, inhibition of NF-κB by BAY 11-7082 can lead to decreased activation of GS188. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor. MEK is part of the MAPK pathway, which is known to activate GS188. Inhibition of MEK by PD98059 can lead to decreased activation of GS188. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a PKC inhibitor. PKC is a known activator of GS188. Inhibition of PKC by Ro-31-8220 can lead to decreased activation of GS188. | ||||||
Tyrphostin AG 1478 | 175178-82-2 | sc-200613 sc-200613A | 5 mg 25 mg | $96.00 $421.00 | 16 | |
AG 1478 is a specific inhibitor of EGFR tyrosine kinase. EGFR is a known activator of many proteins, including GS188. Inhibition of EGFR by AG 1478 can lead to decreased activation of GS188. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $124.00 $526.00 | 55 | |
BAY 11-7085 inhibits NF-κB activation by blocking the cytokine-induced IκBα phosphorylation. Since NF-κB is a known activator of GS188, inhibition of NF-κB by BAY 11-7085 can lead to decreased activation of GS188. | ||||||