Date published: 2026-5-12

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GRP 75 Inhibitors

GRP 75 inhibitors belong to a class of small molecules that have gained prominence in the realm of molecular biology and cellular research. These inhibitors specifically target a protein known as GRP 75, or Glucose-Regulated Protein 75, which is a member of the heat shock protein 70 (HSP70) family. GRP 75 itself is a molecular chaperone protein localized primarily within the mitochondria, the cell's powerhouse organelles. Its primary function is to aid in the correct folding of newly synthesized proteins, as well as to prevent the aggregation of damaged or misfolded proteins within the mitochondria. In doing so, GRP 75 plays a crucial role in maintaining mitochondrial function and cellular homeostasis. GRP 75 inhibitors, as their name suggests, interfere with the activity of GRP 75. By doing so, they disrupt the protein-folding machinery within the mitochondria, leading to the accumulation of misfolded or damaged proteins and ultimately triggering cellular stress responses. Researchers have shown that the inhibition of GRP 75 can have significant implications for understanding fundamental cellular processes and studying diseases related to protein misfolding and mitochondrial dysfunction.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

17-AAG

75747-14-7sc-200641
sc-200641A
1 mg
5 mg
$67.00
$156.00
16
(2)

17-AAG is an HSP90 inhibitor that could reduce the stability and activity of client proteins, potentially leading to decreased expression of GRP 75.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin is a flavonoid with antioxidant properties; it may modulate signaling pathways and reduce the expression of HSPs including GRP 75.

Geldanamycin

30562-34-6sc-200617B
sc-200617C
sc-200617
sc-200617A
100 µg
500 µg
1 mg
5 mg
$39.00
$59.00
$104.00
$206.00
8
(1)

Geldanamycin binds to HSP90, potentially destabilizing its client proteins and leading to decreased GRP 75 expression.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol activates SIRT1 and has antioxidant properties, potentially leading to modulations in cell signaling and decreased GRP 75 expression.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin exhibits anti-inflammatory and antioxidant activities, and it may modulate cellular pathways leading to decreased GRP 75 expression.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$70.00
$215.00
26
(2)

2-Deoxy-D-glucose inhibits glycolysis, potentially leading to energy stress and decreased expression of GRP 75.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG is a major catechin in green tea with antioxidant properties; it may alter signaling pathways and decrease GRP 75 expression.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor, potentially leading to reduced AKT signaling and subsequent reductions in GRP 75 expression.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, which could lead to reduced protein synthesis and potentially decreased GRP 75 expression.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$57.00
$100.00
$250.00
129
(3)

Sorafenib is a multikinase inhibitor that may alter various signaling pathways, potentially leading to decreased GRP 75 expression.