GRO Inhibitors
GRO inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of growth-regulated oncogene (GRO) proteins, a subset of chemokines within the CXC chemokine family. GRO proteins, including GRO-α (CXCL1), GRO-β (CXCL2), and GRO-γ (CXCL3), are key regulators of cellular processes like chemotaxis, proliferation, and the release of pro-inflammatory cytokines. These proteins exert their effects primarily by binding to the CXCR2 receptor, initiating downstream signaling pathways that lead to various cellular responses. GRO inhibitors block the binding of GRO proteins to their receptors, thereby preventing the activation of these signaling pathways. This results in the disruption of processes like neutrophil recruitment, cellular migration, and other inflammatory responses modulated by GRO chemokines.
At the molecular level, GRO inhibitors are typically designed to interfere with either the ligand-receptor interaction or the downstream signaling mechanisms activated by CXCR2. Some GRO inhibitors act by directly binding to the receptor, thereby obstructing the binding site for the GRO chemokines. Others may target intracellular signaling cascades initiated upon CXCR2 activation, such as the MAPK or PI3K pathways, effectively halting the transmission of chemotactic signals. By inhibiting these pathways, the compounds can modulate various cellular activities, particularly those related to immune responses, cell migration, and the modulation of inflammatory environments. The effectiveness of GRO inhibitors is often assessed through in vitro assays that monitor their impact on chemokine-receptor interactions and the downstream cellular responses these interactions elicit.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might downregulate GRO expression by inhibiting the activation of the NF-κB pathway, a key regulator of inflammatory gene transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been suggested to reduce the transcription of inflammatory chemokines like GRO by hindering NF-κB pathway signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is thought to decrease GRO expression by suppressing the activity of JAK/STAT, a pathway commonly involved in the cellular response to growth factors and stress. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin may decrease the synthesis of GRO by downregulating kinase signaling pathways and altering cytokine profiles, which are critical for the chemokine gene expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could potentially lower the expression of GRO proteins through the activation of the Nrf2 pathway, leading to an anti-inflammatory cellular environment. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate is thought to suppress GRO chemokine production by inhibiting key pathways involved in inflammatory responses, such as NF-κB and MAPK. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin might contribute to the downregulation of GRO expression by attenuating NF-κB pathway signaling, thus decreasing the transcription of inflammation-associated genes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could reduce GRO levels by acting as a tyrosine kinase inhibitor, thereby hindering the signaling pathways that lead to the production of this chemokine. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol may suppress the expression of GRO chemokines by inhibiting the synthesis of pro-inflammatory cytokines and through the attenuation of NF-κB-mediated gene transcription. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin may lead to a reduction in GRO expression by obstructing cyclooxygenase pathways, resulting in lower levels of pro-inflammatory prostaglandins. | ||||||