Date published: 2025-10-11

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GRK 5 Inhibitors

GRK 5 Inhibitors belong to a specific category of chemical compounds that play a crucial role in modulating cellular signaling pathways. To understand these inhibitors, it's essential to first grasp the function of GRK 5, which stands for G protein-coupled receptor kinase 5. GRKs are a family of kinases responsible for the regulation of G protein-coupled receptors (GPCRs), which are integral membrane proteins that transmit signals from extracellular molecules to the inside of the cell. GRK 5, in particular, plays a pivotal role in the desensitization and internalization of GPCRs. When a GPCR is activated by binding to its ligand, it initiates a cascade of intracellular events. GRK 5 acts as a negative regulator by phosphorylating the activated receptor, effectively turning it off. This phosphorylation event promotes the binding of β-arrestins to the receptor, leading to its internalization and subsequent desensitization, ultimately attenuating the cellular response to the ligand.GRK 5 Inhibitors, as the name suggests, are compounds specifically designed to target and inhibit the activity of GRK 5. These inhibitors can function by various mechanisms, such as competitively binding to the kinase's active site or altering its conformation, thereby preventing its phosphorylation of GPCRs. By blocking GRK 5, these inhibitors modulate GPCR signaling, prolonging the duration of GPCR activation and amplifying cellular responses. The development and study of GRK 5 Inhibitors are of great interest in the field of molecular pharmacology and cell biology, as they offer a means to manipulate specific signaling pathways for research purposes. Understanding these inhibitors provides valuable insights into the intricacies of GPCR regulation and opens up possibilities for the exploration of novel development strategies.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ro-31-8220 in solution

138489-18-6sc-358721
1 mg
$104.00
2
(0)

Ro-31-8220 acts as a potent inhibitor of G protein-coupled receptor kinase 5 (GRK5), showcasing a remarkable selectivity that influences receptor phosphorylation and subsequent signaling modulation. Its unique interaction profile allows it to disrupt GRK5's regulatory functions, leading to altered receptor activity. The compound's kinetic behavior promotes a fine-tuned response in cellular pathways, highlighting its role in the intricate balance of signal transduction mechanisms.

Parthenolide

20554-84-1sc-3523
sc-3523A
50 mg
250 mg
$79.00
$300.00
32
(2)

Parthenolide is a naturally occurring compound that has demonstrated capability to reduce GRK5 expression. It is believed to exert its effects through the modulation of signaling pathways that control gene expression.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

(-)-Epigallocatechin Gallate, a major component of green tea, has been found to inhibit GRK5 expression. Its action is thought to be mediated through its antioxidant properties and its ability to modulate cell signaling pathways.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin, the active component of turmeric, has been shown to downregulate GRK5 expression. It is believed to exert its effects through its anti-inflammatory properties and modulation of signaling pathways.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol, a polyphenol found in red wine, has potential to inhibit GRK5 expression. Its inhibitory action on GRK5 is thought to be mediated through its antioxidant activity and its ability to modulate signaling pathways.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin, a flavonoid found in many plants, has been observed to reduce GRK5 expression levels. Its effects are believed to be mediated through its antioxidant properties and its ability to modulate signaling pathways.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein, an isoflavone found in soy, has shown potential in inhibiting GRK5 expression. It is believed to exert its effects through its ability to modulate cell signaling pathways.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$150.00
$286.00
$479.00
$1299.00
$8299.00
$915.00
22
(1)

DL-Sulforaphane, a compound found in broccoli, has demonstrated capability to inhibit GRK5 expression. Its inhibitory action is thought to be mediated through its ability to modulate signaling pathways involved in gene expression.

Chrysin

480-40-0sc-204686
1 g
$37.00
13
(1)

Chrysin, a flavonoid found in honey, has been shown to reduce GRK5 expression. Its effects are believed to be mediated through its antioxidant properties and its ability to modulate signaling pathways.

Indirubin

479-41-4sc-201531
sc-201531A
5 mg
25 mg
$112.00
$515.00
4
(1)

Indirubin, a component of traditional Chinese medicine, has potential in inhibiting GRK5 expression. Its inhibitory action on GRK5 is thought to be mediated through its ability to interfere with cell signaling pathways.