GrapL Inhibitors
GrapL inhibitors constitute a specialized chemical class designed to selectively target and modulate the activity of the GrapL protein. GrapL, also known as Grb2-related adaptor protein-like, is a member of the Grb2 family of adaptor proteins, and it plays a pivotal role in signal transduction pathways within the cell. The inhibitors developed for GrapL are intricately designed to interact with the unique structural features of this adaptor protein, aiming to disrupt its normal interactions within the cellular environment and potentially influence various cellular signaling cascades.
The molecular architecture of GrapL inhibitors is precisely tailored to engage specific binding sites on the protein, inducing changes in its conformation and dynamics. As an adaptor protein, GrapL is involved in transmitting signals from cell surface receptors to downstream intracellular effectors, contributing to the regulation of essential cellular processes such as cell growth, differentiation, and survival. In laboratory research, GrapL inhibitors serve as essential tools, allowing scientists to probe the nuanced functions of GrapL in various cellular contexts. By selectively inhibiting GrapL, researchers aim to unravel the complex mechanisms underlying its cellular roles and contributions to cellular homeostasis. The study of GrapL inhibitors contributes to advancing our understanding of adaptor protein-mediated signal transduction pathways and their potential implications in cellular physiology.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, a kinase involved in the PI3K/AKT pathway, which can affect protein synthesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, it may downregulate signaling pathways leading to decreased transcription of certain genes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor, similar to LY294002, it could suppress the transcription of genes downstream of the PI3K pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK, which is upstream of ERK in the MAPK pathway, possibly reducing expression of certain genes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of MEK1/2, leading to downregulation of ERK pathway and affecting gene expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of JNK, which may modulate AP-1 transcription factor activity, influencing gene expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor, potentially altering the expression of genes controlled by this kinase. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, which can cause DNA demethylation, affecting gene expression patterns. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Similar to 5-Azacytidine, it incorporates into DNA and inhibits methylation, potentially altering gene expression. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
A cytidine analog that traps DNA methyltransferases, affecting DNA methylation and gene expression. | ||||||