GPx-5 Activators
Glutathione peroxidases (GPx) are a family of enzymes that play crucial roles in protecting cells from oxidative damage by reducing lipid hydroperoxides to their corresponding alcohols and free hydrogen peroxide to water. The family comprises several isoforms, with GPx-5 being one of them. These enzymes utilize glutathione (GSH) as a cofactor, converting it to its oxidized form, glutathione disulfide (GSSG), in the process. The reaction is reversible, with GSSG being reduced back to GSH by another enzyme called glutathione reductase, in the presence of NADPH.
GPx-5, specifically, has unique characteristics distinguishing it from other members of the GPx family. Predominantly found in the epididymis of mammals, GPx-5 has a role in male fertility, as it safeguards spermatozoa from oxidative stress. This unique location and function make GPx-5 a subject of interest in understanding the biochemistry of male reproduction. Various compounds, both endogenous and exogenous, could potentially influence the activity of GPx-5. While some may enhance the enzyme's function, others could inhibit it. The exact mechanisms by which these substances modulate GPx-5 activity can vary, and research is ongoing to further delineate these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It's known to upregulate the expression of genes associated with antioxidant defense, possibly via the NRF2 pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, found in turmeric, has been shown to increase the expression of various antioxidant enzymes. It may activate transcription factors involved in antioxidant response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol present in grapes. It has potential antioxidative properties and can modulate the expression of genes involved in redox balance. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in many plants. It can influence antioxidant gene expression, possibly by affecting signaling pathways associated with oxidative stress. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy. It may modulate the expression of several antioxidant genes, potentially via its interactions with estrogen receptors. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a major catechin in green tea. It has been implicated in upregulating antioxidant defense mechanisms in various cell types. | ||||||
3H-1,2-Dithiole-3-thione | 534-25-8 | sc-206729 | 100 mg | $388.00 | 1 | |
D3T is a compound known to induce phase 2 detoxification enzymes. Its mechanism may involve the activation of transcription factors that regulate antioxidant response genes. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $67.00 | 4 | |
tBHQ is a synthetic antioxidant. It can induce antioxidant defense genes, possibly through its effect on NRF2 and related signaling pathways. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Lycopene is a carotenoid found in tomatoes. It might influence the expression of antioxidant enzymes in cells, potentially through its antioxidative properties. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Caffeic acid is a hydroxycinnamic acid with potential antioxidant effects. It may modulate the expression of genes related to oxidative stress defense. | ||||||