GPx-4 Inhibitors
GPx-4 inhibitors, short for Glutathione Peroxidase 4 inhibitors, belong to a distinct chemical class characterized by their ability to selectively target and modulate the activity of the GPx-4 enzyme. GPx-4, an essential selenoprotein found in various organisms, plays a pivotal role in cellular defense against oxidative stress and lipid peroxidation. This enzyme acts as a critical component of the cellular antioxidant defense system, safeguarding cell membranes from oxidative damage by catalyzing the reduction of lipid hydroperoxides to their corresponding alcohols. GPx-4's unique function in maintaining membrane integrity sets it apart from other glutathione peroxidases, making it a promising target for research.
Chemically, GPx-4 inhibitors are designed to interfere with the enzymatic activity of GPx-4 by binding to its active site or disrupting its co-factor binding sites. These inhibitors can function by various mechanisms, including competitive binding to the selenocysteine residue within the enzyme's catalytic center or by interfering with the availability of its co-factor, glutathione. By inhibiting GPx-4, these compounds disrupt the enzyme's ability to scavenge lipid hydroperoxides, leading to increased lipid peroxidation and subsequent cell membrane damage.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RSL3 | 1219810-16-8 | sc-507385 | 10 mg | $250.00 | ||
RSL3 binds irreversibly to GPx-4, inhibiting its activity by impairing its active site, which is vital for its enzymatic function. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A has been reported to indirectly down-regulate GPx-4 expression through modulation of transcription factors and signaling pathways. | ||||||
Altretamine | 645-05-6 | sc-210790 | 10 mg | $280.00 | ||
Altretamine may cause oxidative stress by indirectly inhibiting GPx-4, thereby disrupting the cellular redox balance. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can bind to various protein sites and may interact with GPx-4, potentially leading to its inhibition. | ||||||
8-Hydroxy-5-nitroquinoline | 4008-48-4 | sc-233708 sc-233708A sc-233708B | 5 g 100 g 500 g | $50.00 $90.00 $334.00 | 1 | |
8-Hydroxy-5-nitroquinoline has metal chelating properties and may interfere with metalloproteins like GPx-4, altering their expression and function. | ||||||
Erastin | 571203-78-6 | sc-205677 sc-205677A | 5 mg 50 mg | $372.00 $1614.00 | 1 | |
Erastin specifically targets and inhibits system x_c^-, indirectly affecting GPx-4 by depleting its substrate, glutathione. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to decrease mRNA levels of certain genes and may similarly affect GPx-4 expression through transcriptional repression. | ||||||
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $286.00 $442.00 $1532.00 $2975.00 | 26 | |
BSO inhibits the synthesis of glutathione, an essential cofactor for GPx-4, which may reduce GPx-4 activity due to a lack of substrate. | ||||||