Molecular structure of L-Buthionine sulfoximine, CAS Number: 83730-53-4
L-Buthionine sulfoximine (CAS 83730-53-4)
See product citations (26)
Alternate Names:
L-BSO
Application:
L-Buthionine sulfoximine is a glutathione-synthesis inhibitor that activates oxidative stress
CAS Number:
83730-53-4
Purity:
≥97%
Molecular Weight:
222.30
Molecular Formula:
C8H18N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Buthionine sulfoximine (BSO) is a glutathione-synthesis inhibitor that activates oxidative stress through irreversibly inhibiting gamma-GCSc (gamma-glutamylcysteine synthetase). Studies show methylglyoxal (MG) activated caspase-3 is enhanced in the presence of L-Buthionine sulfoximine. It has been reported that L-Buthionine sulfoximine can augment HIV-1 activation through class I HDACIs, and that it can sensitize human breast cancer cells that are anti-hormone resistant to estrogen-induced apoptosis.
L-Buthionine sulfoximine (CAS 83730-53-4) References
- Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. | Reliene, R. and Schiestl, RH. 2006. Carcinogenesis. 27: 240-4. PMID: 16162646
- Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. | Lewis-Wambi, JS., et al. 2008. Breast Cancer Res. 10: R104. PMID: 19061505
- 'Shock and kill' effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence. | Savarino, A., et al. 2009. Retrovirology. 6: 52. PMID: 19486542
- The effects of buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on propyl gallate-treated HeLa cells in relation to cell growth, reactive oxygen species and glutathione. | Han, YH., et al. 2009. Int J Mol Med. 24: 261-8. PMID: 19578799
- Buthionine sulfoximine promotes methylglyoxal-induced apoptotic cell death and oxidative stress in endothelial cells. | Takahashi, K., et al. 2010. Biol Pharm Bull. 33: 556-60. PMID: 20410585
- Regulation of ferroptotic cancer cell death by GPX4. | Yang, WS., et al. 2014. Cell. 156: 317-331. PMID: 24439385
- Impairment in exploratory behavior is associated with arc gene overexpression in the dorsolateral striatum of rats with nigral injection of l-buthionine sulfoximine. | Díaz-Hung, ML., et al. 2018. Neurosci Lett. 687: 26-30. PMID: 30223000
- l-Buthionine Sulfoximine Detection and Quantification in Polyurea Dendrimer Nanoformulations. | Mota, P., et al. 2019. Molecules. 24: PMID: 31461931
- Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance. | Cruz, A., et al. 2020. Antioxidants (Basel). 9: PMID: 32028640
- Zinc L-Carnosine Protects CCD-18co Cells from L-Buthionine Sulfoximine-Induced Oxidative Stress via the Induction of Metallothionein and Superoxide Dismutase 1 Expression. | Ooi, TC., et al. 2020. Biol Trace Elem Res. 198: 464-471. PMID: 32146577
- FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter. | Lin, Z., et al. 2021. J Exp Clin Cancer Res. 40: 50. PMID: 33522955
- Oxygen-Deficient BiOCl Combined with L-Buthionine-Sulfoximine Synergistically Suppresses Tumor Growth through Enhanced Singlet Oxygen Generation under Ultrasound Irradiation. | Wang, H., et al. 2022. Small. 18: e2104550. PMID: 34910856
- Enhanced antitumor effect of L-buthionine sulfoximine or ionizing radiation by copper complexes with 2,2´-biquinoline and sulfonamides on A549 2D and 3D lung cancer cell models. | Cadavid Vargas, JF., et al. 2022. J Biol Inorg Chem. 27: 329-343. PMID: 35247094
- L-buthionine sulfoximine encapsulated hollow calcium peroxide as a chloroperoxidase nanocarrier for enhanced enzyme dynamic therapy. | Liu, B., et al. 2022. Biomaterials. 289: 121746. PMID: 36084482
- Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. | Griffith, OW. 1982. J Biol Chem. 257: 13704-12. PMID: 6128339
Inhibitor of:
γ-GCSm, ABCB7, ADO, ALDH18A1, APIP, CTU2, gamma-GCSc, Gamma-glutamyltransferase (GGT), GCL, GGCT, GLOD4, Glutathione, Glutathione reductase, GPx-3, GPx-4, GPx-7, Grx1, Grx5, GSH-1, GSH-2, GSS, GST, HADHA, HAGHL, L-FABP, LIAS, MGST2, NFS1, NUBP1, PRX IV, PRX V, PSTK, SBP-2, Selenoprotein I, Selenoprotein M, SPTRX-3, TrxR1, TrxR2, TSTD2, Urm1, Vmn2r50, xCT, Yfh1, and ZCSL3.Activator of:
CHAC1, Cytoplasmic CysRS, EG433016, GBP3, GGCT, GGL, GRXCR2, LERK-3, Lingo-2, LRFN2, LUZP2, and SESN3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Buthionine sulfoximine, 500 mg | sc-200824 | 500 mg | $280.00 | |||
L-Buthionine sulfoximine, 1 g | sc-200824A | 1 g | $433.00 | |||
L-Buthionine sulfoximine, 5 g | sc-200824B | 5 g | $1502.00 | |||
L-Buthionine sulfoximine, 10 g | sc-200824C | 10 g | $2917.00 |