Date published: 2026-5-30

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GPR172B Inhibitors

GPR172B, a protein of interest, plays a critical role in various cellular processes, contributing to the regulation of physiological functions within the body. Despite limited elucidation of its precise molecular mechanisms, GPR172B is believed to function as a G-protein coupled receptor (GPCR) with implications in signal transduction pathways. GPCRs are integral membrane proteins involved in diverse signaling cascades, mediating responses to extracellular signals such as hormones, neurotransmitters, and environmental cues. While the specific ligands and downstream effectors of GPR172B remain largely unidentified, its structural homology to other GPCRs suggests potential involvement in cellular processes such as neurotransmission, immune response modulation, and cell proliferation. Inhibition of GPR172B entails disrupting its normal physiological functions, potentially through various mechanisms aimed at attenuating its activity. One possible approach to inhibition involves blocking the binding of endogenous ligands to GPR172B, thereby preventing downstream signaling events and cellular responses. This could be achieved through the development of selective antagonists or inverse agonists that specifically target GPR172B without affecting other GPCRs. Additionally, inhibition of GPR172B may involve modulating its expression levels or cellular localization to reduce its availability for signaling interactions. Targeting intracellular signaling pathways or regulatory proteins that modulate GPR172B activity could also represent viable strategies for inhibition. By elucidating the mechanisms underlying GPR172B inhibition, researchers can gain insights into its physiological roles and potential implications in disease states.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Suramin sodium

129-46-4sc-507209
sc-507209F
sc-507209A
sc-507209B
sc-507209C
sc-507209D
sc-507209E
50 mg
100 mg
250 mg
1 g
10 g
25 g
50 g
$152.00
$214.00
$728.00
$2601.00
$10965.00
$21838.00
$41096.00
5
(1)

Suramin is a polysulfonated naphthylurea that can inhibit various proteins and has been shown to interfere with protein-protein interactions, which may affect GPR172B function indirectly by altering its interaction with other cellular proteins.

Phloretin

60-82-2sc-3548
sc-3548A
200 mg
1 g
$64.00
$255.00
13
(1)

Phloretin is a dihydrochalcone found in apple leaves. It can inhibit various transporters by integrating into cellular membranes and altering membrane fluidity, which can affect the activity of membrane transporters like GPR172B.

Probenecid

57-66-9sc-202773
sc-202773A
sc-202773B
sc-202773C
1 g
5 g
25 g
100 g
$28.00
$39.00
$100.00
$277.00
28
(2)

Probenecid is an organic anion transporter inhibitor, which can also affect the activity of other transporters by competitive inhibition or by altering the transport of endogenous substrates that may regulate GPR172B indirectly.

Amiloride

2609-46-3sc-337527
1 g
$296.00
7
(1)

Amiloride is known to inhibit sodium channels and transporters, and while not specific to GPR172B, its role in modulating ion gradients may indirectly influence the function of various transporters, including GPR172B.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin is a flavonoid that can modulate various biological processes, including transporter activity. It may interact with cellular transporters either directly or by altering the lipid environment of membranes where transporters reside.

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

Verapamil is a calcium channel blocker that can also interact with other transporters and ion channels, potentially altering membrane potential and indirectly affecting transporter function, possibly including GPR172B.

Chlorpromazine

50-53-3sc-357313
sc-357313A
5 g
25 g
$61.00
$110.00
21
(1)

Chlorpromazine is a cationic amphiphilic drug known to intercalate in biological membranes and may affect membrane-associated proteins, potentially altering the function of transporters like GPR172B.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein is an isoflavone that can inhibit tyrosine kinases and may influence various signaling pathways, potentially altering the regulation of transporter proteins, including GPR172B.

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$29.00
$38.00
18
(1)

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that can inhibit the function of various transporters by altering prostaglandin synthesis, which may lead to indirect effects on GPR172B activity.

Tetrandrine

518-34-3sc-201492
sc-201492A
100 mg
250 mg
$56.00
$100.00
9
(2)

Tetrandrine is a bisbenzylisoquinoline alkaloid that can block various ion channels and may influence the function of transporters by altering the ionic balance across membranes, which could indirectly affect GPR172B.