GPR156 Activators
GPR156 Activators represent a unique class of chemical compounds engineered to selectively enhance the activity of GPR156, a member of the G protein-coupled receptor (GPCR) family. GPCRs are integral membrane proteins that play vital roles in cellular signaling, transducing extracellular signals into intracellular responses. The exact function and ligand specificity of GPR156 remain areas of active research, making the development of GPR156 Activators an intriguing endeavor in elucidating the receptor's biological roles. These activators are synthesized through sophisticated chemical processes, with the aim of producing molecules that can specifically interact with GPR156, potentially influencing its natural signaling pathways or uncovering its endogenous ligands. Designing effective GPR156 Activators requires a deep understanding of the receptor's structure, including its transmembrane domains and any potential ligand-binding sites that may be targeted for modulation.
The exploration of GPR156 Activators involves a multidisciplinary research approach, integrating techniques from pharmacology, molecular biology, and structural biology to understand how these compounds interact with GPR156. Scientists employ functional assays, including cAMP assays or calcium mobilization assays, to assess the impact of activators on GPR156-mediated signaling and downstream responses. Structural studies, such as homology modeling and molecular docking, are instrumental in predicting the binding sites and potential interactions between GPR156 and activators. These studies guide the rational design and optimization of activators for increased specificity and efficacy. Additionally, cell-based assays and in vitro systems are utilized to further dissect the receptor's function and evaluate the influence of activators on GPR156-mediated cellular processes. Through this comprehensive research framework, the study of GPR156 Activators aims to advance our understanding of GPCR biology, the functional significance of GPR156, and the intricacies of cellular signaling pathways mediated by this receptor, contributing to the broader field of receptor pharmacology and molecular signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing intracellular cAMP levels, which can affect gene transcription via the activation of cAMP response element-binding (CREB) protein. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors, nuclear receptors that regulate gene transcription, potentially affecting the expression of a wide range of genes, including GPCRs. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3, which may lead to the stabilization of transcription factors and alteration of gene expression profiles. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is known to influence the expression of genes involved in cellular defense mechanisms through the activation of the Nrf2 pathway. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable analog of cAMP that can activate PKA and modulate transcription factor activity, influencing gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may affect gene expression through sirtuin activation and modulation of various signal transduction pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can regulate gene expression by modulating transcription factors, such as NF-κB, and influencing epigenetic changes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the major catechin in green tea, has been shown to influence gene expression through multiple signaling pathways. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO can modulate gene expression as a solvent affecting cellular permeability and signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can lead to changes in chromatin structure and gene expression. | ||||||