GPR120 Inhibitors
GPR120 inhibitors are a class of chemical compounds that specifically target and modulate the activity of the G-protein coupled receptor 120 (GPR120), also known as free fatty acid receptor 4 (FFA4). GPR120 is a transmembrane protein found primarily in various tissues, including adipose tissue, the gastrointestinal tract, and immune cells, where it plays a crucial role in regulating metabolic and inflammatory processes. Inhibitors of GPR120 are designed to interfere with the receptor's signaling pathways, thereby influencing downstream cellular responses.
These inhibitors function by binding to GPR120 and altering its conformation or preventing its activation by endogenous ligands, which are typically long-chain fatty acids such as omega-3 fatty acids. By doing so, they can modulate intracellular signaling cascades associated with GPR120, including the activation of intracellular kinases and the release of secondary messengers like calcium ions. This modulation can have a wide range of effects on cellular physiology, including changes in lipid metabolism, insulin sensitivity, and inflammation. Consequently, GPR120 inhibitors have garnered significant attention in the field of metabolic research and are considered valuable tools for studying the intricate interplay between fatty acid signaling and various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, may alter gene expression and has been studied for its role in inflammation and metabolic pathways, which could potentially impact GPR120 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, found in turmeric, has anti-inflammatory properties and influences various signaling pathways, possibly modulating the expression of GPR120. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, found in grapes and berries, has been shown to influence lipid metabolism and inflammatory responses, potentially affecting GPR120 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid in many fruits and vegetables, exhibits antioxidant and anti-inflammatory properties, and may modulate GPR120 expression as part of its effects on metabolic pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the major catechin in green tea, has anti-inflammatory and metabolic regulatory effects, potentially impacting the expression of GPR120. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a soy isoflavone, has been studied for its role in lipid metabolism and inflammation, which could influence GPR120 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, is involved in gene regulation, and could potentially modulate GPR120 expression as part of its broad effects on cell differentiation and metabolism. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D plays a crucial role in immune function and metabolism, and its potential effects on GPR120 expression may be part of its wider regulatory impacts on cellular processes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, found in several plants, has been studied for its effects on metabolism and inflammation, potentially influencing GPR120 expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone, a thiazolidinedione, is known to influence lipid metabolism and inflammatory responses, potentially modulating GPR120 expression. | ||||||