GP49A Activators
GP49A activators encompass a group of compounds that can modulate immune function and inflammation, potentially influencing the activity of GP49A. These compounds include various metabolites, synthetic drugs, and natural substances that are involved in the intricate signaling networks governing immune responses. For instance, lipid mediators like Lipoxin A4 and PGE2, which play roles in the resolution phase of inflammation, can upregulate the expression of immune inhibitory receptors such as GP49A. Similarly, vitamin D3 and its metabolites can interact with immune cells, potentially leading to enhanced expression of GP49A, which is involved in the modulation of immune responses. Other natural compounds like curcumin, resveratrol, and sulforaphane have been shown to influence the expression of genes involved in immune checkpoints and inflammatory responses, which can affect the expression of GP49A on immune cells.
Chemicals such as pioglitazone and fenofibrate, which act as agonists for peroxisome proliferator-activated receptors (PPARs), can indirectly modulate the expression of inhibitory receptors on immune cells, including GP49A. The action of 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a PPAR-gamma ligand, can also impact the expression of GP49A by altering inflammatory responses. Additionally, dietary components such as omega-3 fatty acids and flavonoids like quercetin have been implicated in the regulation of immune function, which may extend to the modulation of GP49A expression.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipoxin A4 | 89663-86-5 | sc-201060 sc-201060A sc-201060B sc-201060C | 25 µg 50 µg 100 µg 250 µg | $342.00 $485.00 $923.00 $2025.00 | 2 | |
Lipoxin A4 is a lipid mediator that can engage in the resolution phase of inflammation, where GP49A plays a role. Binding to its receptor can trigger anti-inflammatory signals that may lead to the upregulation of GP49A as part of the resolution phase. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 modulates immune responses and can enhance the expression of LILRs. Its metabolites can interact with immune cells, possibly leading to increased expression of GP49A in a regulatory feedback mechanism. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 interacts with its receptors on immune cells, which can upregulate the expression of inhibitory receptors like GP49A as a means of immune response modulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has multiple effects on immune cell regulation. It can modulate the expression of genes related to immune checkpoints, which could include the upregulation of GP49A expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can modulate immune cell activity and inflammatory responses, potentially influencing the expression of inhibitory receptors such as GP49A. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
NDGA affects lipoxygenase pathways and may modulate immune cell signaling, potentially affecting the expression of GP49A. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a PPAR-gamma agonist, can modulate various immune responses and may indirectly enhance the expression of immune inhibitory receptors like GP49A. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate activates PPAR-alpha and could indirectly modulate immune cell functions, potentially increasing the expression of GP49A. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $138.00 $540.00 | 5 | |
15d-PGJ2 is a PPAR-gamma ligand that modulates inflammatory responses and could affect GP49A expression in immune cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane influences Nrf2-dependent antioxidant pathways, which can modulate immune responses and potentially affect GP49A expression. | ||||||