Lipoxin A4 (CAS 89663-86-5)
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Lipoxin A4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. Lipoxin A4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM. Lipoxin A4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition (potent human PKC (protein kinase C) activator inhibits cytotoxicity of natural killer cells), and monocyte migration and adhesion. Biosynthesis occurs in human leukocytes and rat alveolar macrophages. Transcellular biosynthesis occurs via interaction of human neutrophils or granulocytes and platelets. Produced in human nasal polyps and bronchial tissue. Stimulates vasodilation and antagonizes LTD4-induced vasoconstriction. Induces glomerular hyperperfusion and hyperfiltration. Inhibits LTB4- or FMLP-induced leukocyte chemotaxis and blocks the mobilization of Ca2+ and IP3. Inhibits LTB4-induced inflammation in the hamster cheek pouch. Activates protein kinase C13. Regulates human myelopoiesis. Lipoxin A4 is an activator of GPR.
Lipoxin A4 (CAS 89663-86-5) References
- Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils. | Fiore, S., et al. 1992. J Biol Chem. 267: 16168-76. PMID: 1322894
- Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: structure-function relationships. | Lee, TH., et al. 1991. Biochem Biophys Res Commun. 180: 1416-21. PMID: 1659416
- Formation and proliferative effects of lipoxins in human bone marrow. | Stenke, L., et al. 1991. Biochem Biophys Res Commun. 180: 255-61. PMID: 1930222
- Lipoxin A4 inhibits phosphoinositide hydrolysis in human neutrophils. | Grandordy, BM., et al. 1990. Biochem Biophys Res Commun. 167: 1022-9. PMID: 2157419
- Lipoxin formation in human nasal polyps and bronchial tissue. | Edenius, C., et al. 1990. FEBS Lett. 272: 25-8. PMID: 2172016
- Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. | Fiore, S. and Serhan, CN. 1990. J Exp Med. 172: 1451-7. PMID: 2172436
- Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. | Hansson, A., et al. 1986. Biochem Biophys Res Commun. 134: 1215-22. PMID: 2418836
- Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor. | Badr, KF., et al. 1989. Proc Natl Acad Sci U S A. 86: 3438-42. PMID: 2541448
- Lipoxin A4 inhibits leukotriene B4-induced inflammation in the hamster cheek pouch. | Hedqvist, P., et al. 1989. Acta Physiol Scand. 137: 571-2. PMID: 2557732
- Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions. | Edenius, C., et al. 1988. Biochem Biophys Res Commun. 157: 801-7. PMID: 2849436
- Lipoxin A. Stereochemistry and biosynthesis. | Serhan, CN., et al. 1986. J Biol Chem. 261: 16340-5. PMID: 3097008
- Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes. | Ueda, N., et al. 1987. Biochem Biophys Res Commun. 149: 1063-9. PMID: 3122743
- Formation of lipoxins by alveolar macrophages. | Kim, SJ. 1988. Biochem Biophys Res Commun. 150: 870-6. PMID: 3124841
- Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. | Lefer, AM., et al. 1988. Proc Natl Acad Sci U S A. 85: 8340-4. PMID: 3186729
- The action of lipoxin-A on glomerular microcirculatory dynamics in the rat. | Badr, KF., et al. 1987. Biochem Biophys Res Commun. 145: 408-14. PMID: 3593345
- Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. | Ramstedt, U., et al. 1987. J Immunol. 138: 266-70. PMID: 3782800
- Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. | Serhan, CN., et al. 1984. Proc Natl Acad Sci U S A. 81: 5335-9. PMID: 6089195
- Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. | Maddox, JF. and Serhan, CN. 1996. J Exp Med. 183: 137-46. PMID: 8551217
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lipoxin A4, 25 µg | sc-201060 | 25 µg | $342.00 | |||
Lipoxin A4, 50 µg | sc-201060A | 50 µg | $485.00 | |||
Lipoxin A4, 100 µg | sc-201060B | 100 µg | $923.00 | |||
Lipoxin A4, 250 µg | sc-201060C | 250 µg | $2025.00 |