GOLGA6L4 Inhibitors
GOLGA6L4 inhibitors represent a class of chemical compounds specifically designed to inhibit the function of the GOLGA6L4 protein, a member of the golgin subfamily of proteins that are typically associated with the Golgi apparatus. These inhibitors are fine-tuned to target the specific interactions and pathways that GOLGA6L4 is involved in. The inhibition mechanism often involves the disruption of protein-protein interactions that are crucial for the proper functioning of GOLGA6L4 within cellular processes such as vesicle tethering and fusion events that are integral to intracellular transport. By blocking these interactions, GOLGA6L4 inhibitors can prevent the protein from carrying out its role in maintaining Golgi structure and function, which is essential for the processing and sorting of proteins destined for different cellular locations. As GOLGA6L4 is implicated in the modulation of the cytoskeletal network, the inhibitors may also exert their effects by destabilizing the link between GOLGA6L4 and the cytoskeleton, thereby affecting cellular dynamics and morphology.
The specificity of GOLGA6L4 inhibitors lies in their ability to selectively bind to this protein, differentiating it from other golgins and related proteins within the cell. This selectivity ensures that the inhibitors impact only the intended target, minimizing off-target effects that could disrupt other cellular pathways and processes. The chemical structure of these inhibitors is often complex, allowing for the precise interactions with GOLGA6L4's unique binding sites. By impeding the normal function of GOLGA6L4, these inhibitors can alter the balance of protein trafficking and Golgi apparatus organization. The detailed molecular interactions between GOLGA6L4 and its inhibitors typically involve the obstruction of functional domains that are key to the protein's activity, leading to a cascade of effects that result in the dampening of GOLGA6L4's role within the cell. The study and development of GOLGA6L4 inhibitors are driven by the goal to unveil the intricate processes that govern cellular organization and protein distribution, thereby deepening the understanding of cellular homeostasis and the regulation of protein networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase (CDK) inhibitor that can disrupt cell cycle regulation. By inhibiting CDKs, alsterpaullone may indirectly affect the Golgi apparatus structure and function, potentially leading to the inhibition of GOLGA6L4, which is a Golgi-associated protein. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), a small GTPase involved in vesicle formation and trafficking between the Golgi and the endoplasmic reticulum. Inhibition of ARF by Brefeldin A leads to Golgi disassembly, which can impede the function of Golgi-associated proteins like GOLGA6L4. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that disrupts the ionic gradients across the Golgi membrane, affecting Golgi function and protein trafficking. This disturbance can indirectly inhibit the function of GOLGA6L4 by impairing its Golgi-associated activities. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule destabilizer that can disrupt the microtubule network essential for Golgi apparatus positioning and function. As GOLGA6L4 is associated with the Golgi, its function can be inhibited by nocodazole's action on the microtubule network. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that targets dynamin, involved in membrane fission during vesicle trafficking. This can indirectly affect the function of GOLGA6L4 by altering vesicle trafficking to and from the Golgi. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A is a specific inhibitor of the Golgi BFA resistance factor 1 (GBF1), a GEF for ARF1. Its inhibition disrupts Golgi structure and function, which could result in the functional inhibition of GOLGA6L4. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Ilomastat is a matrix metalloproteinase inhibitor that may affect the extracellular matrix remodeling, which can influence Golgi function and the trafficking of proteins, including the potential inhibition of GOLGA6L4 function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, which are key regulators of cellular processes, including vesicle trafficking. This inhibition could indirectly affect the function of GOLGA6L4 within the Golgi apparatus. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine is an inhibitor of alpha-mannosidase II, an enzyme involved in glycoprotein processing within the Golgi. Its inhibition could lead to a dysfunctional glycosylation process, indirectly affecting GOLGA6L4 function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin blocks N-linked glycosylation, an essential process in the Golgi. This can lead to Golgi stress and potentially impede the function of Golgi-associated proteins like GOLGA6L4. | ||||||