GNL1 Inhibitors
GNL1 inhibitors are theoretical chemical compounds that would specifically target the GNL1 protein, known as Guanine Nucleotide-Binding Protein-Like 1. GNL1 is a GTP-binding protein that plays a significant role in ribosome biogenesis and cellular proliferation. It belongs to the large GTPase family and is involved in nucleolar assembly and function. Inhibiting GNL1 would potentially interfere with its GTPase activity, affecting the processes of ribosome assembly and other nucleolar functions. Although specific inhibitors of GNL1 have not been extensively documented in scientific literature, the concept involves designing molecules that can modulate the activity of this protein to study its function in greater detail.
GNL1 inhibitors are small molecules or peptides engineered to bind to the active site of the GNL1 protein. These compounds might inhibit the binding or hydrolysis of GTP by occupying the GTP-binding domain, thus blocking the protein's essential functions. Structure-based drug design methods could be employed to develop these inhibitors, utilizing computational modeling to predict how different compounds interact with the three-dimensional structure of GNL1. Additionally, such inhibitors might target protein-protein interactions involving GNL1, disrupting its association with other proteins crucial for nucleolar activities. Research into GNL1 inhibitors would involve synthesizing candidate molecules, assessing their binding affinity and specificity, and evaluating their impact on cellular processes related to GNL1 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate GNL1 by inhibiting histone deacetylases, leading to tighter chromatin that is less accessible for the transcription machinery to express GNL1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferases, 5-Azacytidine could decrease GNL1 expression through the demethylation of gene promoter regions, suppressing its initiation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D could decrease GNL1 expression by binding to DNA at the transcription initiation complex, obstructing RNA polymerase movement and GNL1 mRNA synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin may reduce GNL1 protein levels by inhibiting mTOR, a key kinase in promoting translation initiation and protein synthesis, including the synthesis of GNL1. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may decrease GNL1 expression by intercalating into DNA and RNA, disrupting nucleic acid replication and transcription processes essential for GNL1. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 could downregulate GNL1 by competitively binding to BET bromodomains, preventing the recruitment of transcriptional machinery to the GNL1 gene locus. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 might reduce GNL1 expression by inhibiting the proteasome, leading to the accumulation of ubiquitinated proteins that can repress transcription factors for GNL1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 could decrease GNL1 expression by targeting PI3K, thereby reducing the activation of downstream protein kinase B, which is crucial for GNL1 gene transcription. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 may downregulate GNL1 by inhibiting MEK, which subsequently reduces the phosphorylation and activity of transcription factors responsible for GNL1 expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 might reduce GNL1 levels by inhibiting JNK, which is necessary for the activation of transcription factors that drive GNL1 gene transcription. | ||||||