Gm5849 Activators
Gm5849, a predicted gene with putative calcium ion and calcium-dependent protein binding activities, is implicated in autocrine signaling, leukocyte migration, and neutrophil aggregation processes. Located in the cytoplasm, extracellular space, and nucleus, Gm5849 exhibits versatility in its functional involvement. The activation of Gm5849 is intricately linked to calcium signaling pathways, highlighting the significance of calcium-dependent interactions in regulating its functions.
Calcium-binding proteins such as calmodulin directly activate Gm5849 by binding to its calcium-binding domains, initiating downstream signaling events. Indirect activators, including thapsigargin, ionomycin, and BAPTA-AM, modulate intracellular calcium levels, impacting calcium-dependent protein interactions and promoting Gm5849 activation. Furthermore, inhibitors like FK506 and W7 interfere with calcium-dependent processes, indirectly enhancing Gm5849 activation. Signaling cascades initiated by PMA and U73122 also contribute to Gm5849 activation through their influence on calcium-dependent protein binding. The summarized activation mechanisms underscore the intricate interplay of calcium-related signaling pathways and specific chemical regulators in modulating Gm5849 functions. This understanding provides valuable insights into potential strategies for targeted activation in cellular contexts associated with autocrine signaling, leukocyte migration, and neutrophil aggregation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calcium-binding protein influencing Gm5849 through direct binding. Calmodulin serves as a mediator in calcium-dependent signaling cascades, directly activating Gm5849 by binding to its calcium-binding domains. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Endoplasmic reticulum Ca²⁺-ATPase inhibitor leading to elevated cytosolic calcium. Thapsigargin indirectly activates Gm5849 by enhancing overall cellular calcium levels, promoting calcium-dependent protein interactions. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Calcium ionophore facilitating calcium influx into cells. Ionomycin indirectly activates Gm5849 by inducing elevated cytosolic calcium, resulting in enhanced calcium-dependent protein binding activity. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Inositol trisphosphate receptor inhibitor modulating intracellular calcium release. 2-APB indirectly activates Gm5849 by influencing calcium flux, subsequently promoting calcium-dependent protein interactions. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Calcineurin inhibitor blocking dephosphorylation events in calcium signaling. FK506 indirectly activates Gm5849 by influencing calcium-dependent protein binding activity through inhibition of calcineurin activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Calcium chelator sequestering intracellular calcium ions. BAPTA-AM indirectly activates Gm5849 by reducing cytosolic calcium levels, modulating calcium-dependent protein binding and promoting target activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Protein kinase C activator initiating signaling cascades. PMA indirectly activates Gm5849 through downstream kinase-mediated events, impacting calcium-dependent protein binding activity and promoting activation. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
Calmodulin antagonist interfering with calcium-calmodulin interactions. W7 indirectly activates Gm5849 by blocking calmodulin, disrupting calcium-dependent protein binding activity and enhancing target activation. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Calcium channel blocker inhibiting calcium influx. Ruthenium Red indirectly activates Gm5849 by reducing cytosolic calcium, impacting calcium-dependent protein interactions and promoting target activation. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
Calcium chelator binding extracellular calcium ions. EGTA indirectly activates Gm5849 by reducing extracellular calcium availability, impacting calcium-dependent protein binding and promoting target activation. | ||||||