Gm44 Activators
Mageb11 activators are a category of biochemical compounds that have been identified for their role in modulating the function of the protein known as MAGE family member B11. This protein is part of a larger family of MAGE proteins, which have been studied extensively for their various intracellular roles. The activators function through an array of mechanisms to enhance the activity of MAGE family member B11, each employing a different pathway or targeting a different molecular process. For instance, some activators work by increasing the levels of certain intracellular messengers, such as cyclic AMP (cAMP), which in turn activates specific kinases known to phosphorylate proteins. Phosphorylation is a common post-translational modification that can alter a protein's activity, subcellular localization, or interaction with other proteins. As such, compounds like forskolin and isoproterenol raise cAMP levels, leading to the activation of protein kinase A (PKA), which may influence the activity of MAGE family member B11 either directly or indirectly through the phosphorylation of associated proteins.
Other Mageb11 activators function by altering the cellular concentration of ions like calcium, which is a critical second messenger in numerous signaling cascades. For example, ionomycin acts as a calcium ionophore, facilitating an increase in intracellular calcium levels, which can activate calcium-dependent proteins such as calmodulin-dependent kinases (CaMKs). These enzymes can phosphorylate a range of substrates, potentially affecting the functionality of proteins associated with MAGE family member B11. Additionally, some activators may engage with the epigenetic machinery of the cell, influencing gene expression patterns without altering the underlying DNA sequence. Compounds such as epigallocatechin gallate (EGCG) and sodium butyrate are known to impact DNA methyltransferases and histone deacetylases, respectively. These effects can lead to changes in the chromatin structure, thereby modulating the transcription of genes whose products may interact with MAGE family member B11 or form part of its regulatory network.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP). Elevated cAMP levels can activate PKA (protein kinase A), which may then phosphorylate substrates that interact with MAGE family member B11, enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate proteins that associate with MAGE family member B11 or alter the cellular context in a way that promotes its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calmodulin-dependent kinases (CaMKs). These kinases could phosphorylate proteins that are part of the MAGE family member B11 regulatory network, potentially enhancing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit DNA methyltransferases, leading to changes in the methylation status of genes. While not directly enhancing MAGE family member B11, it can influence the epigenetic landscape in which MAGE family member B11 operates, potentially affecting its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, an NAD+-dependent deacetylase, which can deacetylate histones and transcription factors, altering gene expression patterns that could include genes interacting with MAGE family member B11, thereby enhancing its activity. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy through inhibition of the acetyltransferase EP300, which could lead to the degradation of negative regulators of MAGE family member B11, thus enhancing its functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the transcription factor NF-κB, which may enhance the transcription of genes that are part of the MAGE family member B11 network or its regulatory elements, potentially enhancing its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), which may lead to the stabilization and activation of β-catenin, a transcription coactivator that could enhance the expression of genes interacting with MAGE family member B11. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that leads to hyperacetylation of histones, potentially enhancing the transcription of genes that may interact with MAGE family member B11 or influence its regulatory network. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that increases cAMP levels, similarly to forskolin, and can activate PKA. PKA may phosphorylate proteins within the MAGE family member B11 network, enhancing its activity. | ||||||