Gm239 Activators
Myrfl Activators constitute a specialized assortment of chemical compounds that have been identified or designed to promote the functional activity of the myelin regulatory factor-like (Myrfl) protein. Myrfl is involved in the complex regulation of myelin, which is the insulating sheath around nerve fibers crucial for the proper conduction of electrical impulses within the nervous system. The chemical entities classified as Myrfl Activators interact with various signaling pathways that, in turn, play a pivotal role in the modulation of gene expression related to myelin formation and maintenance. These activators are diverse in structure and function, engaging different molecular targets and processes within the cell. For instance, some compounds might increase intracellular levels of secondary messengers such as cyclic AMP (cAMP), which in turn activate protein kinases instrumental in the phosphorylation of transcription factors. Such phosphorylation events can lead to the upregulation of genes under the regulatory domain of Myrfl, thereby enhancing its functional output.
The mechanism of action of Myrfl Activators involves a cascade of intracellular events that ultimately converge on the enhancement of Myrfl activity. These chemicals can act directly or indirectly to modulate the activity of enzymes, receptors, or ion channels that are upstream of Myrfl. By doing so, they affect the signaling networks that dictate the expression of myelin-related genes. Some activators, like forskolin, work by stimulating adenylate cyclase, which increases the production of cAMP, whereas others may influence the pathways that govern the maturation and differentiation of oligodendrocytes-the cells responsible for myelin production. In addition, certain Myrfl Activators might alter the intracellular concentration of ions such as calcium, thereby influencing signaling pathways that are sensitive to changes in the ionic environment of the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
cAMP can enhance the cAMP-dependent PKA signaling pathway, which is involved in the phosphorylation of transcription factors that regulate myelination. Enhanced PKA activity may lead to increased expression of genes involved in myelination, which could enhance the functional activity of Myrfl by promoting myelin gene expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP serves as a membrane-permeable analog of cAMP that can activate PKA. Activation of PKA may lead to upregulation of myelin-specific gene expression, potentially enhancing the activity of Myrfl by increasing the transcription of myelin genes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to increased levels of cAMP and activation of PKA. This activation can enhance myelin protein expression, augmenting Myrfl's role in myelin gene regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is involved in the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes, which express myelin proteins. This differentiation process could enhance Myrfl activity by upregulating myelin gene expression in these cells. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P binds to its receptors, initiating signaling pathways that regulate oligodendrocyte function and myelination. Activation of these pathways can enhance Myrfl activity by promoting the maturation of oligodendrocytes and myelin production. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea facilitates the release of nitric oxide, which can modulate the differentiation of oligodendrocyte precursor cells, potentially enhancing Myrfl activity by influencing myelin gene expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore that raises intracellular calcium levels, potentially triggering signaling cascades that regulate myelination gene expression, thereby enhancing the activity of Myrfl. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is implicated in myelination signaling pathways. This activation might enhance Myrfl activity by promoting the expression of myelin-related genes. | ||||||
L-3,3′,5-Triiodothyronine, Sodium Salt | 55-06-1 | sc-205725 | 250 mg | $113.00 | ||
T3 influences the expression of genes involved in myelination. By doing so, it could enhance Myrfl activity by increasing the transcription of genes that Myrfl regulates. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, potentially leading to activation of the Wnt/β-catenin signaling pathway, which is involved in myelination. This could enhance Myrfl activity by promoting the transcription of myelin-specific genes. | ||||||