Gm1381 Activators
Fam47e Activators are a group of chemical compounds that influence various cellular pathways, leading to the enhancement of the functional activity of Fam47e. Compounds such as Epigallocatechin Gallate (EGCG) and Resveratrol act on proteins involved in cellular stress response and sirtuin pathways, respectively. EGCG's role in inhibiting protein kinases and Resveratrol's activation of sirtuins both serve to promote cellular defense mechanisms against oxidative stress and improve cell survival, processes in which Fam47e is involved. Similarly, inhibitors such as SB216763 and Lithium target the enzyme GSK-3, stabilizing proteins within the Wnt signaling pathway and enhancing the activity of Fam47e related to cell survival and neuroprotection. Metformin and Nicotinamide Mononucleotide (NMN) influence AMPK and sirtuin activities, respectively, modulating cellular energy homeostasis and health, thereby supporting the role of Fam47e in metabolic stress responses.
Further, compounds like Curcumin and Rapamycin modulate NF-κB and mTOR pathways, which are integral to inflammation, cell survival, and growth. These modulations enhance the function of Fam47e by fostering anti-inflammatory responses and adapting to growth signaling changes. Autophagy inducers such asSpermidine and Trehalose promote cellular cleanup processes, which can lead to the activation of Fam47e functions related to cellular maintenance and renewal. Sulforaphane, through the activation of the Nrf2 pathway, enhances Fam47e's role in the cellular antioxidant defense, while Quercetin's modulation of cell stress pathways facilitates Fam47e activity in these contexts. These chemicals collectively act on a diverse set of cellular pathways to ensure that Fam47e's role in maintaining cellular integrity, responding to stress, and promoting survival is enhanced.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits several protein kinases and has been found to enhance the activity of proteins involved in the cellular stress response, potentially leading to the functional activation of Fam47e by supporting its role in the response to oxidative stress. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate sirtuins, which can improve cell survival under stress by deacetylating key substrates. This activity can enhance the function of Fam47e by promoting cellular resilience mechanisms where Fam47e is involved. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763 is a glycogen synthase kinase 3 (GSK-3) inhibitor that can activate the Wnt signaling pathway. By inhibiting GSK-3, SB216763 can stabilize proteins associated with the Wnt pathway, potentially enhancing Fam47e activity related to this pathway. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin can activate AMP-activated protein kinase (AMPK), leading to alterations in cellular energy homeostasis. This activation can enhance the function of Fam47e as part of the cellular response to metabolic stress. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium acts as a GSK-3 inhibitor, which can enhance pathways related to cell survival and neuroprotection. The inhibition of GSK-3 by lithium can indirectly enhance the function of Fam47e in related signaling pathways. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor to NAD+ that can enhance sirtuin activity. Increased sirtuin activity can support cellular health mechanisms where Fam47e plays a role, thus enhancing its functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can suppress NF-κB signaling, which is involved in inflammation and cell survival. By suppressing NF-κB, curcumin can enhance the function of Fam47e by promoting anti-inflammatory responses where Fam47e is implicated. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which plays a significant role in cell growth and survival. Inhibition of mTOR can lead to a cellular response that enhances the function of Fam47e within the affected pathways. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to induce autophagy, a process involved in cell maintenance. This induction can enhance the function of Fam47e by promoting cellular cleanup processes that Fam47e is associated with. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which regulates the expression of antioxidant proteins. Activation of Nrf2 can enhance the function of Fam47e in cellular defense mechanisms against oxidative stress. | ||||||