Glycophorin E Inhibitors
Glycophorin E inhibitors represent a class of chemical entities specifically designed to interact with and inhibit the function of Glycophorin E, a protein likely involved in cellular processes such as the stabilization of the cell membrane and possibly in cell-to-cell interactions. These inhibitors, while diverse in their chemical structure, share the common feature of targeting the biochemical activity of Glycophorin E. Their inhibitory action is typically based on the binding affinity towards regions of the protein that are crucial for its function, effectively disrupting its normal activity within the cell membrane. The specificity of these inhibitors is critical, as they are tailored to the unique aspects of Glycophorin E's structure, aiming to alter its stability or interrupt its interaction with other membrane constituents. This precise targeting is achieved through molecular interactions that may involve hydrogen bonding, hydrophobic forces, or ionic interactions, which enable the inhibitors to bind selectively to Glycophorin E.
The inhibition of Glycophorin E by these chemical compounds can have various consequences on the cellular level, depending on the role of Glycophorin E in membrane integrity and signaling. By interfering with Glycophorin E, the inhibitors can affect the protein's ability to maintain the cell's structural integrity, potentially altering the dynamics of the cell membrane. This can lead to modifications in the mechanical properties of the cell surface, which may impact the cell's response to its environment. Moreover, the inhibition of Glycophorin E may also have downstream effects on cellular communication pathways, given that the protein could be involved in signal transduction mechanisms. These inhibitors operate by a non-competitive mechanism, meaning that they do not directly compete with natural ligands or substrates of Glycophorin E but rather exert their effects by binding to distinct sites, causing conformational changes that reduce the protein's functional activity. The result is a finely tuned decrease in Glycophorin E's contribution to cell processes without directly affecting the expression levels of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent non-specific inhibitor of protein kinases. By broadly inhibiting kinase activity, it can prevent phosphorylation events that are necessary for the function of Glycophorin E, thus indirectly leading to its functional inhibition. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone that acts as a tyrosine kinase inhibitor. Since tyrosine phosphorylation can regulate the function of various transmembrane proteins, inhibiting these kinases could result in decreased functional activity of Glycophorin E by reducing its phosphorylated state. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a selective inhibitor of protein kinase C (PKC). PKC is involved in signaling pathways that regulate the activity of transmembrane proteins. Inhibition of PKC could lead to reduced activity of Glycophorin E by limiting its phosphorylation and activation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKCs. It inhibits PKC-mediated signaling that could affect the phosphorylation state and, consequently, the function of Glycophorin E. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). PI3K signaling is crucial for many cellular processes, including membrane protein trafficking. Inhibition of PI3K may disrupt Glycophorin E localization and stability at the membrane. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can impair intracellular signaling leading to membrane protein dysfunction. Similar to LY294002, it can indirectly lead to Glycophorin E functional inhibition by disturbing its membrane localization and stability. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can phosphorylate transmembrane proteins, modulating their function. PP2 could indirectly inhibit Glycophorin E functionality by preventing its Src kinase-mediated phosphorylation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. By inhibiting MEK, PD98059 may indirectly lead to decreased Glycophorin E activity due to alterations in cell signaling that affect transmembrane proteins. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a PKC inhibitor that can decrease Glycophorin E function by inhibiting PKC-mediated phosphorylation, which could be essential for Glycophorin E activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which can influence various cellular processes including the activity of membrane proteins. Inhibiting this kinase could indirectly limit Glycophorin E function by altering its signaling environment. | ||||||