Glutathione Activators
Glutathione activators form a versatile array of compounds crucial for sustaining optimal glutathione levels within cells, playing pivotal roles in cellular antioxidant defenses and redox homeostasis. N-Acetylcysteine (NAC) emerges as a direct activator, supplying cysteine-an indispensable amino acid-for glutathione synthesis. Simultaneously, Alpha-Lipoic Acid indirectly supports glutathione levels through the recycling of oxidized glutathione and active participation in redox reactions, reinforcing cellular antioxidant capacity. S-Adenosylmethionine (SAMe) actively contributes to glutathione synthesis by engaging the transsulfuration pathway, providing methyl groups essential for cysteine formation. The trace element Selenium, while not a direct component, indirectly influences glutathione levels by supporting the activity of glutathione peroxidase, a critical selenoprotein integral to antioxidant defense. Meanwhile, Curcumin and Quercetin act as indirect activators, orchestrating the modulation of the Nrf2 pathway and thereby enhancing the expression of genes integral to glutathione metabolism.
Directly contributing to glutathione synthesis, Resveratrol, L-Glutamine, Cysteine, and Methionine furnish the essential building blocks necessary for maintaining optimal cellular redox balance. Nrf2 activators like Sulforaphane indirectly stimulate glutathione synthesis by facilitating the nuclear translocation of Nrf2, amplifying the cellular antioxidant response. Additionally, Vitamin C (Ascorbic Acid) assumes an indirect supportive role by effectively regenerating oxidized glutathione, ensuring the perpetuation of cellular redox equilibrium. Collectively, this diverse ensemble of glutathione activators provides researchers with a comprehensive toolkit. This arsenal facilitates exploration into the intricate regulatory mechanisms that govern glutathione levels, offering valuable insights into cellular antioxidant defenses and contributing significantly to the understanding of redox homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine (NAC) is a precursor of glutathione, providing cysteine, a crucial amino acid for glutathione synthesis. It directly supports the availability of cysteine for glutathione production, thereby enhancing cellular glutathione levels. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-Lipoic Acid is an antioxidant that indirectly supports glutathione levels by recycling oxidized glutathione and other antioxidants. It participates in redox reactions and helps regenerate reduced glutathione, contributing to the overall cellular antioxidant defense. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
Ademetionine is involved in the transsulfuration pathway, indirectly contributing to glutathione synthesis. It provides methyl groups for the conversion of homocysteine to cysteine, a precursor for glutathione, thereby influencing cellular glutathione levels. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is an essential trace element that indirectly influences glutathione peroxidase activity. Glutathione peroxidase, a selenoprotein, utilizes selenium to catalyze the reduction of hydrogen peroxide and organic hydroperoxides, protecting cells from oxidative damage and potentially enhancing overall cellular glutathione levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenol from turmeric, acts as an indirect activator by modulating the Nrf2 pathway. Nrf2 regulates the expression of antioxidant enzymes, including those involved in glutathione synthesis. Curcumin's activation of Nrf2 can lead to increased glutathione levels, contributing to cellular antioxidant defense. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, indirectly activates glutathione synthesis by influencing the Nrf2 pathway. It enhances the expression of Nrf2-dependent genes, including those involved in glutathione metabolism. Through this mechanism, quercetin can contribute to cellular antioxidant capacity by promoting glutathione production. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in red grapes, indirectly activates glutathione synthesis through the Nrf2 pathway. It enhances Nrf2 activity, leading to increased expression of genes involved in glutathione metabolism. This activation contributes to cellular antioxidant defenses and supports glutathione levels. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $36.00 $46.00 $97.00 $372.00 $719.00 | 2 | |
L-Glutamine is an amino acid that serves as a precursor for glutathione synthesis. It provides the necessary building blocks for glutathione production, directly contributing to the cellular pool of glutathione. The availability of L-glutamine influences the rate of glutathione synthesis, impacting cellular redox homeostasis. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $50.00 $110.00 $440.00 $1128.00 $2135.00 | 1 | |
Cysteine is a key amino acid directly involved in the synthesis of glutathione. It serves as the rate-limiting substrate, and its availability influences the rate of glutathione production. Supplementation with cysteine provides a direct means to support cellular glutathione levels, contributing to antioxidant defense and redox balance. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine is an essential amino acid that indirectly influences glutathione levels by participating in the transsulfuration pathway. It contributes to the synthesis of cysteine, a precursor for glutathione, and influences the overall cellular capacity for glutathione production. Methionine availability can impact glutathione synthesis and cellular redox status. | ||||||