Glut11 Activators
Glut11 activators encompass a diverse range of chemical compounds that enhance the functional activityGlut11 Activators are a diverse set of chemical compounds that enhance the functional activity of Glut11 through various mechanisms, impacting glucose transport and cellular energy homeostasis. AMP-activated protein kinase activator and Berberine, both known to activate AMPK, might indirectly enhance Glut11 activity by promoting its translocation to the plasma membrane. Similarly, insulin, a primary regulator of glucose uptake, could potentially upregulate Glut1. Iodoacetate, a glycolytic inhibitor, could create a demand for increased glucose transport via Glut11 by causing intracellular glucose accumulation. Pioglitazone and Ciglitazone, both PPARγ agonists, might enhance Glut11 activity.
Furthermore, Genistein's inhibition of tyrosine kinase signaling pathways could indirectly augment Glut11's activity by modifying the signaling context in which Glut11 operates. Metformin, a well-known antidiabetic agent, could also enhance Glut11 function through AMPK activation, leading to increased glucose transport into cells. Forskolin's action on adenylate cyclase might boost cAMP levels, thereby activating PKA and potentially affecting Glut11's translocation and activity. Resveratrol, through SIRT1 activation, could influence Glut11, enhancing glucose uptake processes. Chromium picolinate, believed to improve insulin sensitivity, might indirectly enhance Glut11 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
AMPK activation enhances cellular glucose uptake by promoting the translocation of glucose transporters to the plasma membrane. Although it generally targets other glucose transporters, it could potentially enhance Glut11 activity indirectly by similar mechanisms if Glut11 is subject to AMPK regulation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin stimulates glucose uptake by promoting the translocation of glucose transporters from intracellular vesicles to the plasma membrane. While typically associated with Glut4, if Glut11 is also responsive to insulin signaling, its functional activity could be enhanced in a similar manner. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist that enhances glucose uptake in adipose and muscle tissue, primarily via Glut4. If Glut11 is similarly regulated by PPARγ, pioglitazone could enhance its functional activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an isoquinoline alkaloid that has been shown to activate AMPK. As such, it could enhance Glut11 activity indirectly if Glut11 is subject to AMPK regulation, promoting glucose uptake by increasing the translocation of Glut11 transporters to the membrane. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, could enhance Glut11 activity by modulating insulin signaling pathways. If Glut11 is downstream of any tyrosine kinase-dependent signaling cascades, genistein could indirectly influence its activity by altering the signaling environment. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin is an antidiabetic drug that acts in part through the activation of AMPK. If Glut11 is regulated by AMPK, metformin could enhance its activity by promoting the cellular uptake of glucose and potentially increasing the membrane presence of Glut11. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels and the activation of PKA. If Glut11 is regulated by pathways involving cAMP/PKA, forskolin could enhance Glut11 activity by promoting its translocation to the plasma membrane. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which has been implicated in the regulation of glucose transporters. If Glut11 is influenced by SIRT1 or related pathways, resveratrol could indirectly enhance its activity by promoting glucose uptake mechanisms. | ||||||
Chromium Picolinate | 14639-25-9 | sc-204685 sc-204685A | 5 g 25 g | $214.00 $667.00 | 1 | |
Chromium picolinate is suggested to enhance insulin sensitivity, which could lead to an increased activity of insulin-regulated glucose transporters. If Glut11 is insulin-sensitive, chromium picolinate could increase its functional activity indirectly. | ||||||
Ciglitazone | 74772-77-3 | sc-200902 sc-200902A | 5 mg 25 mg | $104.00 $428.00 | 10 | |
Ciglitazone is another PPARγ agonist that could potentially enhance Glut11 activity if Glut11 is regulated by PPARγ, thereby promoting glucose uptake similarly to pioglitazone. | ||||||