Glut11 Inhibitors
Chemical inhibitors of Glut11 can operate through various mechanisms to impede the protein's glucose transport function. Phloretin, a dihydrochalcone, can inhibit Glut11 by directly binding to its glucose transport domain, effectively blocking the entry of glucose into cells. Similarly, quercetin, a flavonoid, can competitively bind to Glut11's glucose binding sites, preventing glucose from engaging with the transporter. WZB117, which is known to block GLUT1, can also interfere with the same domain in Glut11, based on the structural similarities among glucose transporters. Cytochalasin B, by targeting the cytoplasmic site, prevents the conformational changes essential for glucose translocation through Glut11, thus acting as an inhibitor.
STF-31, although selective for GLUT1, can inhibit Glut11 by disrupting the glucose binding mechanism. Fasentin's role in interfering with the intracellular trafficking of glucose transporters includes preventing Glut11 from reaching the plasma membrane. Apigenin and luteolin, both flavones, can inhibit protein kinases that regulate Glut11, thus leading to a reduction in its phosphorylation, activation, and glucose transport function. Myricetin, another flavonoid, binds to the extracellular glucose binding site of Glut11, inhibiting its ability to uptake glucose. Methyl-3,4-dephostatin can indirectly inhibit Glut11 by modulating the phosphorylation of proteins involved in Glut11's function, whereas kaempferol, by binding to the glucose binding site of the transporter, prevents glucose from interacting with Glut11, thus inhibiting its transport activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin is a dihydrochalcone, a type of natural phenol. It inhibits various glucose transporters, and as Glut11 is a glucose transporter, phloretin can inhibit Glut11 by directly binding to the glucose transport domain, thus preventing glucose from entering the cell. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that is known to inhibit glucose transporters by competitively binding to the glucose binding sites. As Glut11 is a glucose transporter, quercetin can inhibit Glut11 function by competing with glucose for the binding sites. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
WZB117 is a small molecule inhibitor that blocks the glucose uptake function of GLUT1. Due to structural similarities among glucose transporters, WZB117 can functionally inhibit Glut11 by obstructing the glucose binding site. | ||||||
Cytochalasin B | 14930-96-2 | sc-3519 | 5 mg | $199.00 | 19 | |
Cytochalasin B is a mycotoxin that is known to inhibit glucose transporters by binding to the cytoplasmic site, which prevents conformational changes required for glucose translocation. This action can inhibit Glut11 by preventing the necessary conformational shift for its function. | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $187.00 | 3 | |
STF-31 selectively inhibits GLUT1, but due to the conserved nature of glucose transporters, it can inhibit Glut11 by interfering with the glucose binding mechanism, thereby reducing the glucose transport activity. | ||||||
Fasentin | 392721-37-8 | sc-215012 sc-215012A | 5 mg 25 mg | $128.00 $449.00 | ||
Fasentin is a compound that interferes with the intracellular trafficking of glucose transporters. It can inhibit Glut11 by preventing its translocation to the plasma membrane, thus reducing glucose uptake. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavone that can inhibit protein kinases, which may regulate the activity and expression of glucose transporters. Inhibition of these kinases can result in decreased Glut11 function due to lack of proper activation and membrane localization. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $97.00 $188.00 $260.00 $510.00 $1022.00 | 3 | |
Myricetin is a flavonol that inhibits several GLUTs by binding to the extracellular glucose binding site, and similarly, it can inhibit Glut11 by blocking the binding site, thus preventing glucose uptake. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is a flavone that can inhibit protein kinases, affecting the activity of glucose transporters. It can inhibit Glut11 by preventing its phosphorylation and activation, which is necessary for its glucose transport function. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is another flavonoid that can inhibit GLUT transporters by directly interfering with the glucose binding site. It can inhibit Glut11 by binding to this site and preventing glucose from binding and being transported into the cell. | ||||||