Glucose-6-Phosphate Dehydrogenase Inhibitors
Glucose-6-phosphate dehydrogenase (G6PD) inhibitors represent a class of chemical compounds that specifically target and suppress the activity of the G6PD enzyme. This enzyme plays a pivotal role in the pentose phosphate pathway, which is fundamental for maintaining the reduced form of the coenzyme nicotinamide adenine dinucleotide phosphate (NADPH) in cells. NADPH, in turn, is vital for various cellular processes, including the regeneration of reduced glutathione, which helps in combating oxidative stress within cells. Therefore, the inhibition of G6PD can impact cellular health and metabolism significantly by disrupting the balance of redox reactions and the production of NADPH.
The diverse compounds that inhibit G6PD often exert their effects through different mechanisms. Some inhibitors bind directly to the active site of the enzyme, thereby preventing the substrate, glucose-6-phosphate, from accessing it. In contrast, others might act indirectly, either by competing with essential cofactors like NADP+ or by modifying the enzyme's structural conformation, thereby reducing its catalytic efficiency. Naturally occurring flavonoids, such as quercetin and fisetin, are known to interact with the enzyme and modulate its activity. Other compounds, like 6-aminonicotinamide, compete with cofactors to impede the enzymatic process. The wide array of mechanisms through which these inhibitors act underscores the enzyme's intricate regulatory importance in cellular metabolism and redox balance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DHEA | 53-43-0 | sc-202573 | 10 g | $109.00 | 3 | |
DHEA inhibits G6PD by competing with the substrate, glucose-6-phosphate. The binding of DHEA induces a conformational change in the enzyme, reducing its catalytic efficiency. This in turn affects the pentose phosphate pathway, leading to reduced NADPH production. | ||||||
6-Aminonicotinamide | 329-89-5 | sc-278446 sc-278446A | 1 g 5 g | $153.00 $390.00 | 3 | |
6-Aminonicotinamide is a competitive inhibitor against the cofactor NADP+. Its binding prevents the normal conversion of glucose-6-phosphate to 6-phosphogluconolactone, thus inhibiting the enzyme and the pentose phosphate pathway. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $42.00 $102.00 $322.00 | 3 | |
Methylene Blue acts indirectly to inhibit G6PD. It facilitates the conversion of NADPH to NADP+, leading to a decrease in the available NADPH. This indirectly suppresses the activity of G6PD, as the enzyme's activity is closely linked with NADPH levels. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $265.00 | 2 | |
Atovaquone is known to inhibit G6PD. Its mechanism of action is likely related to its function in disrupting mitochondrial electron transport. However, the exact mechanism of G6PD inhibition by atovaquone is not completely understood. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG from green tea inhibits G6PD by interacting with its substrate binding site. This interaction results in the blockage of the active site, preventing glucose-6-phosphate from accessing it and, consequently, halting the enzyme's function in the pentose phosphate pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid known to inhibit G6PD activity. It is believed to bind to the active site of the enzyme, preventing substrate binding. As a result, the conversion of glucose-6-phosphate to 6-phosphogluconolactone is halted, impacting the pentose phosphate pathway. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $46.00 $68.00 | 1 | |
Chlorogenic Acid, a major polyphenol in coffee, has demonstrated G6PD inhibitory properties. It's believed to inhibit G6PD by binding to its active site, preventing substrate access and enzyme activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, the active compound in turmeric, has shown G6PD inhibitory activity. It's postulated that curcumin interacts with the active site or other crucial regions of the enzyme, preventing the typical catalytic function and subsequent NADPH production. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenol that has shown inhibitory effects on G6PD. Its mechanism of action is believed to be associated with its interaction with the enzyme's active site, preventing normal substrate binding and activity. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $95.00 $184.00 $255.00 $500.00 $1002.00 | 3 | |
Myricetin, a naturally occurring flavonoid, has been shown to inhibit G6PD. The molecule likely binds to the enzyme's active site, blocking substrate binding and enzyme activity, thus affecting the pentose phosphate pathway. | ||||||