GLCCI1 Activators
GLCCI1 activators encompass a diverse array of chemical compounds that indirectly potentiate the activity of GLCCI1 through distinct yet convergent signaling pathways. Forskolin and rolipram, for instance, elevate intracellular cAMP levels, leading to the activation of PKA; this, in turn, can enhance the phosphorylation of transcription factors that boost GLCCI1 expression within glucocorticoid responses. Similarly, isoquinoline acts upon PKC to foster post-translational modifications that could amplify GLCCI1 activity, while lithium chloride and SB216763 impede GSK-3, thereby potentially augmenting glucocorticoid receptor activity and consequent GLCCI1 function. Curcumin and resveratrol, on the other hand, modulate inflammation and deacetylate the glucocorticoid receptor, respectively, with both outcomes likely leading to an upsurge in GLCCI1 activity. Pioglitazone, by activating PPARγ, could work in tandem with glucocorticoids to enhance the receptor's transcriptional activity, positively influencing GLCCI1 expression.
The GLCCI1 activators represent a spectrum of chemicals that intrinsically enhance the functional dynamics of GLCCI1 through various cellular signaling pathways. These activators include Forskolin and Rolipram, which both lead to increased cAMP levels, thereby activating PKA and potentially promoting the phosphorylation of transcription factors. This cascade of events is believed to upregulate GLCCI1 activity, particularly within the context of glucocorticoid responses. Isoquinoline, by stimulating PKC, may also enhance GLCCI1 activity by influencing post-translational modifications of proteins within the glucocorticoid signaling pathway. Meanwhile, Lithium Chloride and SB216763 target GSK-3, with the inhibition of this kinase possibly leading to a boost in glucocorticoid receptor activity and subsequent GLCCI1 function.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate transcription factors that enhance GLCCI1 expression and activity, particularly in glucocorticoid responses in cells. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, which leads to increased cAMP levels in the cell. This accumulation of cAMP can lead to the activation of PKA, thus promoting GLCCI1 activity as part of the glucocorticoid response mechanism. | ||||||
Isoquinoline | 119-65-3 | sc-255224 sc-255224A | 5 g 100 g | $26.00 $58.00 | ||
Isoquinoline is known to stimulate PKC, which can then enhance the phosphorylation of proteins involved in the glucocorticoid signaling pathway, potentially increasing the activity of GLCCI1 by post-translational modifications. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB, a transcription factor that regulates inflammation. By inhibiting NF-κB, curcumin could enhance glucocorticoid receptor-mediated transcriptional activity, indirectly increasing the functional activity of GLCCI1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, an NAD+-dependent deacetylase, which can deacetylate the glucocorticoid receptor, potentially enhancing its activity and thereby increasing the expression and function of GLCCI1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, which can regulate glucocorticoid receptor function through phosphorylation. Inhibition of GSK-3 may result in enhanced glucocorticoid receptor activity, promoting GLCCI1 function. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 is a potent and selective inhibitor of GSK-3, which could potentiate glucocorticoid receptor-mediated transcription and enhance GLCCI1 activity by similar mechanisms as Lithium Chloride. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPARγ agonist which can synergize with glucocorticoids to enhance glucocorticoid receptor-mediated gene expression, potentially increasing the activity of GLCCI1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can directly enhance glucocorticoid receptor-mediated transcriptional activation, which includes upregulation of GLCCI1 expression and activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an MEK inhibitor that may shift the balance of cellular signaling pathways to favor glucocorticoid receptor-mediated transcription, thus potentially enhancing the activity of GLCCI1. | ||||||