GILZ Inhibitors
GILZ inhibitors, short for Glucocorticoid-Induced Leucine Zipper Inhibitors, represent a class of chemical compounds that target a specific protein known as GILZ. GILZ, or Glucocorticoid-Induced Leucine Zipper, is a transcription factor that plays a crucial role in the regulation of various cellular processes, including inflammation and immune response. GILZ is typically induced by glucocorticoid hormones, which are involved in a wide range of physiological processes, such as metabolism, immune regulation, and stress response. In many instances, the upregulation of GILZ by glucocorticoids is associated with anti-inflammatory and immunosuppressive effects. However, there are situations where excessive GILZ activity can have detrimental consequences, such as impaired immune response and increased susceptibility to infections. GILZ inhibitors are designed to modulate the activity of GILZ, either by preventing its expression or interfering with its function, with the aim of fine-tuning the immune and inflammatory responses in a more controlled and targeted manner.
These inhibitors can function through various mechanisms, including binding to GILZ directly, disrupting its interactions with other cellular proteins, or inhibiting the signaling pathways that lead to its activation. By doing so, GILZ inhibitors have the ability to mitigate the overexpression of GILZ and consequently restore a more balanced immune response in certain pathological conditions. This class of compounds holds promise for research into better understanding the intricate regulation of the immune system and inflammation, paving the way for future developments in medical science. Additionally, GILZ inhibitors may offer insights into the broader field of transcription factor modulation, opening up new avenues for studying and manipulating gene expression in various contexts beyond immunology and inflammation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound from turmeric, has been shown to downregulate GILZ expression. Its anti-inflammatory properties might be attributed to its ability to modulate various signaling pathways, including the inhibition of NF-κB activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol found in grapes, has potential to decrease GILZ expression. It might influence signaling pathways and transcription factors involved in inflammation and stress responses. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in many plants, has the potential to inhibit GILZ expression. It exerts anti-inflammatory effects and might influence various signaling pathways involved in cell survival and apoptosis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a soy isoflavone, may decrease GILZ expression. It has anti-inflammatory properties and modulates several signaling pathways, potentially influencing GILZ expression. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin, a flavonoid found in various plants, may inhibit GILZ expression. It exhibits anti-inflammatory effects and modulates signaling pathways involved in cellular responses to stress. | ||||||
Baicalin | 21967-41-9 | sc-204638 sc-204638A sc-204638B sc-204638C | 1 mg 25 mg 1 g 5 g | $55.00 $110.00 $220.00 $260.00 | 4 | |
Baicalin, a flavonoid from Scutellaria baicalensis, has potential to decrease GILZ expression. Its anti-inflammatory and antioxidant activities are of interest in this context. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol, a flavonol found in several plants, might downregulate GILZ expression. It exhibits anti-inflammatory properties and influences various signaling pathways. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin, a flavone found in many fruits and vegetables, may inhibit GILZ expression. Its anti-inflammatory and antioxidant activities could be linked to its effects on signaling pathways. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin, a flavone found in honey and propolis, has potential to decrease GILZ expression. Its anti-inflammatory and antioxidant properties might modulate cellular responses to stress and inflammation. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin, a flavonoid from Scutellaria baicalensis, could downregulate GILZ expression. It exhibits anti-inflammatory effects and influences signaling pathways involved in inflammation and cell survival. | ||||||