GDF-9B Inhibitors
GDF-9B inhibitors belong to a distinctive chemical class that primarily targets the growth differentiation factor 9B (GDF-9B), a member of the transforming growth factor beta (TGF-β) superfamily. GDF-9B, also known as BMP-15, plays a crucial role in regulating ovarian folliculogenesis and oocyte maturation. This chemical class is designed to modulate the activity of GDF-9B, thereby influencing key cellular processes involved in reproductive physiology. GDF-9B is predominantly expressed in oocytes and is essential for proper follicular development, ovulation, and fertility in females. Its inhibition by molecules within this class disrupts the intricate signaling cascades associated with oocyte growth and maturation.
The structural diversity within GDF-9B inhibitors allows for selective and potent interference with the biological functions of GDF-9B. These inhibitors often act by binding to specific regions of the GDF-9B protein, thereby altering its conformation and impeding its ability to interact with cellular receptors. This class of compounds has garnered significant attention in the realm of reproductive biology research, as the precise control of GDF-9B activity holds promise for advancing our understanding of ovarian function and fertility mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
This inhibitor blocks the activity of certain TGF-β type I receptors, which can interfere with downstream signaling of TGF-β family proteins, including GDF-9. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
It is a small molecule inhibitor of the TGF-β type I receptor kinase, which may disrupt GDF-9 signaling in the TGF-β pathway. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
A selective inhibitor of ALK5, ALK4, and ALK7, which are receptors that can be involved in the signaling pathways of TGF-β superfamily members such as GDF-9. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
This molecule inhibits ALK5, potentially reducing the signaling cascade initiated by TGF-β family proteins, possibly affecting GDF-9's function. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $86.00 | 3 | |
A TGF-βRI kinase inhibitor that can interrupt signaling pathways related to GDF-9's function in the TGF-β superfamily. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
As a TGF-β receptor I kinase inhibitor, it can affect the signaling of TGF-β superfamily members including GDF-9. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
A selective inhibitor of TGF-β type I receptor ALK5 kinase, which can influence the pathway of GDF-9. | ||||||
ITD 1 | 1099644-42-4 | sc-507349 | 10 mg | $220.00 | ||
A selective TGF-β inhibitor that can indirectly affect GDF-9 signaling by disrupting TGF-β superfamily pathways. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $321.00 $1350.00 | 2 | |
An ALK4, ALK5, and ALK7 inhibitor, potentially interfering with GDF-9's role in TGF-β signaling. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $100.00 $408.00 | 6 | |
While not a direct inhibitor, it has shown to reduce TGF-β activity and could, therefore, have an impact on GDF-9 mediated signaling. | ||||||