GDF-9B Antibody (F-7): sc-271824

GDF-9B Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects GDF-9B protein of human and hamster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GDF-9B (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Growth/differentiation factor 9B (GDF-9B), also known as bone morphogenetic protein 15 (BMP15), plays a crucial role in female reproductive biology, as GDF-9B is exclusively expressed in oocytes and is essential for the regulation of ovarian folliculogenesis. GDF-9B′s specific localization in the oocyte is vital because GDF-9B influences the development and maturation of ovarian follicles, which are critical for fertility. GDF-9B interacts with other growth factors, such as GDF-9, to orchestrate the complex signaling pathways that govern oocyte development and function. Understanding GDF-9B′s role in these processes is important for advancing reproductive health research and developing potential therapeutic strategies for fertility-related issues.

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GDF-9B Antibody (F-7) References:

1. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.  |  Aaltonen, J., et al. 1999. J Clin Endocrinol Metab. 84: 2744-50. PMID: 10443672
2. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.  |  Galloway, SM., et al. 2000. Nat Genet. 25: 279-83. PMID: 10888873
3. Mutation analysis of the growth differentiation factor-9 and -9B genes in patients with premature ovarian failure and polycystic ovary syndrome.  |  Takebayashi, K., et al. 2000. Fertil Steril. 74: 976-9. PMID: 11056243
4. Bmp15 mutations and ovarian function.  |  Galloway, SM., et al. 2002. Mol Cell Endocrinol. 191: 15-8. PMID: 12044914
5. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
6. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
7. A novel growth differentiation factor-9 (GDF-9) related factor is co-expressed with GDF-9 in mouse oocytes during folliculogenesis.  |  Laitinen, M., et al. 1998. Mech Dev. 78: 135-40. PMID: 9858711

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GDF-9B Antibody (F-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-GDF-9B Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GDF-9B Antibody (F-7) Specifications

Alternate Product Name: BMP15

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 268-350

Epitope Target: GDF-9B

Epitope Species: human

Product Reactivity/Detection: mature and precursor GDF-9B

Species Reactivity/Detection: human, hamster

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for GDF-9B Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin