GDF-15 Activators
Growth Differentiation Factor 15 (GDF-15) is a member of the Transforming Growth Factor β (TGF-β) superfamily, a group of proteins involved in the regulation of cellular processes such as proliferation, differentiation, and apoptosis. GDF-15, specifically, is a stress-responsive cytokine that is produced and secreted by various cell types in response to physiological and pathological stimuli. Its expression can be induced by conditions like cellular stress, injury, inflammation, and certain metabolic challenges. Due to its pivotal role in mediating various cellular responses, the activation of GDF-15 has garnered attention from researchers keen to understand its intricate pathways and regulatory mechanisms.
GDF-15 activators are compounds or factors that can stimulate the expression or secretion of GDF-15, enhancing its activity or augmenting its signaling pathways. The regulation of GDF-15 can be intricate, involving various upstream mediators and downstream targets. Activators can operate at different levels – they might influence the transcription of the GDF-15 gene, modulate its translation into the active protein, or interact with the protein post-translationally to stabilize or further facilitate its signaling. As our understanding of GDF-15's role in cellular processes expands, the identification and elucidation of these activators become paramount. By shedding light on the intricate interactions and pathways associated with GDF-15, activators offer a deeper insight into the physiological and cellular contexts in which this protein operates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
This is a widely used drug for type 2 diabetes. While its main action is to increase insulin sensitivity and reduce hepatic glucose production, it has also been shown to increase GDF-15 levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, Rapamycin has various effects on cellular metabolism and has been shown to upregulate GDF-15. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
As a therapeutic agent, Cisplatin induces DNA damage and cellular stress, leading to increased GDF-15 expression in certain contexts. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Another therapeuitc compound, it can induce cellular stress and consequently increase GDF-15 levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A therapeutic compound, its cytotoxic effects can lead to upregulation of GDF-15 in some cells. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $124.00 | 7 | |
An antiretroviral compound, it has been reported in some studies to increase GDF-15 levels. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
A statin used for cholesterol management, it has been shown to increase GDF-15 expression in some contexts. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
An agent that can induce DNA damage and might upregulate GDF-15. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
A compound that induces mitochondrial dysfunction, it can lead to an upregulation of GDF-15. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
It induces endoplasmic reticulum stress, which can increase GDF-15 expression in certain cell types. | ||||||