GDF-15 Inhibitors
GDF-15 inhibitors belong to a class of small molecules or biologics designed to specifically target and interact with Growth Differentiation Factor 15 (GDF-15), a protein that plays a crucial role in various physiological processes within the human body. GDF-15, also known as MIC-1 (Macrophage Inhibitory Cytokine-1) or PLAB (Placental Transforming Growth Factor Beta), is a member of the transforming growth factor beta (TGF-β) superfamily. It is secreted by a variety of cells, including macrophages, cardiomyocytes, and certain tumor cells, and it exerts its effects by binding to specific receptors on the cell surface.
The primary function of GDF-15 in its natural state is to regulate cellular growth, differentiation, and survival. However, aberrant overexpression of GDF-15 has been implicated in several pathological conditions, including cancer, inflammation, and metabolic disorders. GDF-15 inhibitors, therefore, are designed to modulate the activity of this protein. They work by either blocking its interaction with its receptors or inhibiting downstream signaling pathways. By doing so, GDF-15 inhibitors have the ability to offer a new avenue for research and development in various fields, as the precise manipulation of GDF-15 activity can have significant implications for understanding disease mechanisms.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol found in turmeric, is known to modulate various signaling pathways and has potential anti-inflammatory properties. It might reduce GDF-15 expression by inhibiting NF-κB activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural compound found in grapes. It is known for its antioxidant properties and may suppress GDF-15 expression through its inhibitory effects on oxidative stress and inflammation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, has demonstrated anti-inflammatory and antioxidant properties. It could potentially downregulate GDF-15 expression via its ability to modulate inflammatory pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It is known for its anticancer and anti-inflammatory properties, and it might reduce GDF-15 expression by modulating oxidative stress and inflammation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid with potent anti-inflammatory properties. It may reduce GDF-15 expression by inhibiting the activation of pro-inflammatory transcription factors. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a PPAR-γ agonist, is studied in the research of type 2 diabetes. It might suppress GDF-15 expression through its insulin-sensitizing and anti-inflammatory effects. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin is a widely used anti-inflammatory drug. It might downregulate GDF-15 expression through its inhibitory effects on the COX enzymes, leading to reduced prostaglandin production. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that might reduce GDF-15 expression by inhibiting COX enzymes and reducing the production of pro-inflammatory mediators. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major catechin in green tea, has antioxidant and anti-inflammatory properties. It might inhibit GDF-15 expression by modulating various signaling pathways associated with inflammation and oxidative stress. | ||||||