GCSAML Activators
GCSAML Activators represent a putative group of chemicals that, by influencing intracellular signaling cascades, can modulate the expression or function of the Germinal center-associated signaling and motility-like protein. This modulation can be attributed to the alteration of second messenger concentrations such as cAMP by compounds like Forskolin, Isoproterenol, and Rolipram, which activate adenylate cyclase or inhibit phosphodiesterase, respectively. Elevated cAMP levels can lead to the activation of PKA and subsequent transcription of cAMP-responsive genes. Similarly, the application of ionophores like Ionomycin and A-23187 can increase intracellular calcium, which serves as a pivotal messenger in many signaling pathways, potentially leading to changes in the transcription of genes that respond to calcium signaling.
These activators also encompass agents that influence epigenetic regulation and transcription factor activity. Polyphenols like EGCG and Curcumin modulate numerous signaling pathways and can alter the activity of various transcription factors, possibly affecting the transcription of genes like GCSAML. Similarly, the utilization of specific kinase pathway inhibitors such as LY294002 and SB203580 might induce cellular compensatory mechanisms that lead to the upregulation of alternative signaling routes and gene expression patterns, including the expression of GCSAML.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can promote the transcription of genes through the PKA pathway, potentially enhancing GCSAML expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
As a beta-adrenergic agonist, isoproterenol can increase cAMP levels, potentially leading to transcriptional activation of genes including GCSAML via the PKA signaling pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which could lead to transcriptional regulation of genes involved in cellular signaling pathways, potentially including GCSAML. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that can increase intracellular calcium levels, which might enhance the transcription and activity of proteins modulated by calcium signaling, including GCSAML. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A-23187 is another calcium ionophore that raises intracellular calcium concentration, possibly affecting the expression of calcium-regulated genes like GCSAML. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP breakdown which could boost the expression of genes controlled by the cAMP-responsive elements, possibly GCSAML. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to modulate various signaling pathways, possibly affecting gene expression profiles including that of GCSAML by altering transcription factor activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin influences numerous signaling pathways; its impact on nuclear factor-kappa B might enhance the transcription of genes under its control, potentially GCSAML. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cAMP analog that can pass through cell membranes and activate cAMP-dependent pathways, potentially upregulating genes like GCSAML. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate sirtuin pathways and modulate transcription factors, which may affect the expression of genes such as GCSAML. | ||||||