GATA-2 Activators
Common GATA-2 Activators include, but are not limited to 5-Azacytidine CAS 320-67-2, Hydroxyurea CAS 127-07-1, Retinoic Acid, all trans CAS 302-79-4, Sodium Butyrate CAS 156-54-7 and Etoposide (VP-16) CAS 33419-42-0.
The GATA family of transcription factors, of which GATA-2 is a prominent member, is recognized for its pivotal role in regulating the expression of genes involved in cell development and differentiation. GATA-2, specifically, is integral to hematopoiesis, the process by which blood cells are formed. Within this context, GATA-2 orchestrates the differentiation and proliferation of hematopoietic stem cells and progenitor cells. The protein achieves this by binding to specific DNA sequences in the promoters of target genes, subsequently modulating their transcription. The precise regulation of GATA-2 activity is crucial for maintaining cellular homeostasis, as anomalies in its function have been linked to various hematological disorders.
GATA-2 Activators encompass a suite of chemical entities designed to augment the activity of the GATA-2 transcription factor. These activators, by enhancing the transcriptional activity of GATA-2, could potentially amplify its role in guiding the differentiation and proliferation of hematopoietic cells. The mechanism of action of such activators may vary, ranging from direct binding and stabilization of the GATA-2 protein to modulating upstream signaling pathways that influence GATA-2 activity. Detailed characterization of these activators can provide insights into the molecular intricacies of GATA-2 regulation and function. Furthermore, these chemical activators serve as vital tools in research settings, aiding in the dissection of GATA-2's role in hematopoiesis and other cellular processes. As the field advances, a deeper understanding of these activators can further unravel the complexity of transcriptional regulation and its broader implications in cellular biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can reactivate silenced genes. Given GATA-2's role in hematopoiesis, alterations in methylation might upregulate its expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
An HDAC inhibitor that affects histone acetylation and can lead to changes in gene expression, potentially inducing GATA-2. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase II inhibitor which might induce GATA-2 expression as part of the DNA damage response in hematopoietic cells. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Forms DNA adducts and cross-links, potentially inducing GATA-2 expression as part of the DNA damage response in hematopoietic contexts. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Known to influence gene expression and cellular differentiation, it might affect GATA-2 expression in hematopoietic cells. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Affects multiple signaling pathways and can alter gene expression, potentially inducing GATA-2 in certain cellular contexts. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
Causes DNA alkylation damage. The resulting DNA repair processes might stimulate GATA-2 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Affects various cellular pathways and might influence GATA-2 expression through its effects on chromatin remodeling and transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that might induce GATA-2 by altering chromatin structure and gene expression in hematopoietic cells. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
By modulating cellular responses and signaling, rosiglitazone might influence GATA-2 expression. | ||||||