GAS41 Activators
The chemical class identified as GAS41 Activators encompasses a range of molecular entities that are involved in the selective upregulation of GAS41, which stands for Glioma-Amplified Sequence 41. GAS41 is a component of the transcriptional regulatory complexes, such as the histone acetyltransferase (HAT) complexes and the YEATS domain-containing family of proteins. It plays a critical role in chromatin remodeling and gene expression by interacting with chromatin-associated proteins and influencing the organization of the chromatin structure. The YEATS domain, in particular, is known for recognizing and binding to specific histone modifications, which can affect the accessibility of DNA for transcription factors and, consequently, the transcription of genes. Activators of GAS41 are designed to enhance the biological activity of GAS41, potentially modifying its interaction with chromatin or other components of the transcriptional machinery.
GAS41 Activators can be small molecules, peptides, or biologics that have been identified through various screening methods for their ability to increase the activity of GAS41. The interaction between these activators and GAS41 may lead to changes in the protein's conformation, promote its integration into chromatin remodeling complexes, or alter its affinity towards specific epigenetic marks on histones. Such alterations could have a profound impact on the transcriptional regulation of genes, particularly those involved in cell division and growth. The development and study of GAS41 Activators shed light on the fundamental processes of gene expression regulation and chromatin dynamics. These activators serve as important tools for probing the function of GAS41 within the nucleus and contribute to an advanced understanding of the molecular mechanisms that govern chromatin remodeling and transcriptional control. By precisely modulating the activity of GAS41, researchers can investigate the role this protein plays in the maintenance of chromatin structure and the broader implications for cellular function and genomic stability.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent pan-histone deacetylase inhibitor that can amplify GAS41 activity by modulating chromatin structure, thereby facilitating the transcriptional programs in which GAS41 is implicated. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide inhibits sirtuin histone deacetylases, which could lead to an enriched acetylated chromatin environment, potentially enhancing GAS41's role in chromatin remodeling and gene regulation. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic Acid inhibits histone acetyltransferases, which might indirectly enhance GAS41 function by altering the balance of histone acetylation and thereby influencing chromatin dynamics where GAS41 is active. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
Caffeic Acid Phenethyl Ester is a specific inhibitor of histone acetyltransferases, potentially promoting an environment that could increase GAS41 activity in chromatin structure maintenance and transcription regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to inhibit histone acetyltransferase, which may foster chromatin conditions that accentuate GAS41's activity in transcriptional regulation and chromatin remodeling by modulating histone acetylation levels. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a polyphenol, inhibits DNA methyltransferases, potentially creating a chromatin state that enhances GAS41's role in the regulation of gene expression and chromatin architecture. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine inhibits DNA methyltransferases, possibly leading to a reduction in DNA methylation and thus fostering a state that could amplify GAS41's activity in chromatin remodeling and gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to G-C rich DNA sequences and can inhibit Sp1 transcription factor, potentially altering gene expression patterns in a manner that enhances GAS41's role in chromatin structure and function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to intercalate into DNA and alter DNA structure and function. This could indirectly enhance GAS41 activity by influencing chromatin organization and gene expression that GAS41 participates in. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is an endocrine disruptor that has been shown to interact with nuclear receptors and alter gene expression. This might lead to changes in chromatin structure that could enhance GAS41's functional activity. | ||||||